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Beckwith-Wiedemann syndrome occurs in about 1 in 15,000 births in the general population, and the specific form of Angelman's syndrome that is of concern--an imprinting defect--occurs even more rarely, in about 1 in 300,000 births.
In the latest finding, Susan Malcolm of the Institute of Child Health in London and her colleagues report in the March 23 LANCET on two children who developed a rare type of mental retardation called Angelman's syndrome.
As the largest pediatric neurology clinic in the United States, treating more than 20,000 young patients each year, the Clinic excels in general child neurology care and multiple specialties including, but not limited to: Autism, Cerebral Palsy, Multiple Sclerosis, Muscular Dystrophy, Rett Syndrome, Batten's Disease, Angelman's Syndrome, Sleep Disorders, Epilepsy, Stroke and Headache.
Joe, of Newquay, Cornwall, had meningitis at a week old and 14 months later also had a lung virus and Angelman's Syndrome, causing epilepsy.
Danielle's condition is known as Prader-Willi syndrome but she also has Angelman's Syndrome, causing learning difficulties and problems with movement such as involuntary laughter and jerking of the hands.
Most patients with Angelman's syndrome also have sleep problems, and medications such as melatonin or clonidine can be helpful.
Even the exact number of children with Angelman's Syndrome in Britain remains a mystery.
Cady, 12, has a possible diagnosis of Angelman's syndrome.