anemia

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Related to Anemia of chronic disease: iron deficiency anemia, hemolytic anemia
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19) Anemia of chronic disease is typically as a consequence of an inflammatory condition, an autoimmune or neoplastic condition, prolonged illness, trauma, chronic infection involving parasitic, fungal, bacterial, or viral loads, and, in the elderly or ill, polypharmacy.
Differential diagnosis of anemia of chronic disease and iron deficiency anemia and combination of iron deficiency anemia and anemia of chronic disease anemia in patients with rheumatoid arthritis IDA ACD COMBI anemia Mean erythrocyte Reduced Normal Reduced to normal volume Color index Reduced Normal Reduced to normal Serum iron Reduced Normal Reduced Total iron binding Elevated Normal Normal to elevated capacity Serum ferritin Reduced Normal Reduced to normal to elevated Serum transferrin Elevated Normal Normal to elevated Serum erythropoietin Elevated Elevated Elevated Relative No Yes Yes erythropoietin deficiency IDA: Iron deficiency anemia; ACD: Anemia of chronic disease; COMBI: Combination of IDA and ACD.
Anemia of chronic disease (ACD), also referred to as anemia of inflammation, is clearly responsible for many cases of anemia observed in the elderly.
Hepcidin is the key regulator of iron metabolism and responsible for the iron restriction leading to anemia of chronic disease.
Anemia of chronic disease is the second most prevalent form after that caused by iron deficiency and develops as a result of acute or a chronic activation of immune response.
In patients with anemia of chronic disease that is unresponsive to erythropoietin, this hepcidin ELISA may be used to verify that increased serum hepcidin is at least partly responsible for the erythropoietin-resistant anemia.
Together, the Access Soluble Transferrin Receptor (sTfR) Assay and the sTfR/log ferritin index (sTfR Index) act as an aid in the diagnosis of iron-deficiency anemia (IDA) and the differential diagnosis of IDA and anemia of chronic disease (ACD).
Several diseases result in normocytic anemia, including aplastic anemia, acute blood loss, hemolytic anemia, and anemia of chronic disease (Gaspad, 2005; Young, Calado, & Scheinberg, 2006).
A test for iron, total iron-binding capacity, percentage saturation of iron-binding capacity, ferritin and soluble transferrin receptor levels will distinguish anemia of chronic disease (ACD) from iron-deficiency anemia (IDA).
The diseased control group consisted of patients with rheumatoid arthritis and anemia of chronic disease.
Increased cytokine production has been implicated in the development of anemia of chronic disease and can worsen the anemia in patients with CKD and CHF--thus completing this cycle of disease progression (Silverberg, 2003).
This condition, over time, results in anemia of chronic disease.
Access sTfR Assay and the sTfR/Log Ferritin Index (sTfR Index) are used as an aid in the diagnosis of iron-deficiency anemia, and the differential diagnosis of that and anemia of chronic disease.
Recent developments in the anemia of chronic disease.
Anemia of chronic disease and hyperbilirubinemia can decrease the specificity of an iron deficiency diagnosis based on hematofluorometry-determined increases in the ratio of ZnPPIX to heme.