Interestingly our study revealed that anemia of chronic disease
, anemia secondary to bone marrow involvement and iron deficiency anemia remained the major causes of anemia when HL and DLBCL patients were analyzed separately.
[sup], Dysregulated iron status has been suspected to be linked to anemia of chronic disease
and to ACVD.
CHr and TfR1 are not affected by inflammation, malignancy, or anemia of chronic disease
. Serum TfR1 assays are not widely available and are not standardized for use in infants and children.
In addition, the MCV (calculating the average volume of erythrocytes) should be assessed because low MCV suggests anemia of chronic diseases
(ACD), anemia of renal disease, or iron deficiency anemia (Thomas, 2004).
In a study of 60 anemic nursing home residents, 23.3% had iron deficiency anemia, 13.3% had anemia of chronic disease
, and 10.0% had anemia of renal insufficiency.
Unless there are complex causes of anemia, iron deficiency and anemia of chronic disease
do not present with reduction in the other cell lines.
(2003), Anemia of chronic disease
: past, present and future.
Laboratory tests demonstrated anemia of chronic disease
diagnosed by a hematocrit of 25% associated with a low reticulocyte production index, high serum ferritin, and an elevated erythrocyte sedimentation rate (91 mm/hr), with polyclonal hypergammaglobulinemia and hypoalbuminemia on serum protein electrophoresis.
Blood investigations showed anemia of chronic disease
, elevated CRP level, and prolonged in vitro bleeding time.
The potential impact of anemia of chronic disease
Anemia of chronic disease
(ACD) was when patient had a decreased serum iron levels with decreased TIBC and increased in marrow iron stores.
Progress in understanding the pathogenesis of the anemia of chronic disease
. Blood 1992;80:1639-47.
Anemia of chronic disease
(ACD), also known as anemia of inflammation, is a hypoproliferative anemia that develops in response to systemic illness or inflammation such as infection, cancer, and autoimmune conditions.
Interestingly, these smaller hepcidin isoforms occur only in serum of patients with diseases that are associated with increased concentrations of hepcidin-25, such as acute myocardial infarction (AMI),  sepsis, anemia of chronic disease
(ACD), metabolic syndrome, and chronic kidney disease (CKD) (Fig.
Together, the Access Soluble Transferrin Receptor (sTfR) Assay and the sTfR/log ferritin index (sTfR Index) act as an aid in the diagnosis of iron-deficiency anemia (IDA) and the differential diagnosis of IDA and anemia of chronic disease