For further analysis, causes of pancytopenia have been grouped into: Aplastic anemia, Megaloblastic
anemia, pancytopenia due to Infiltration (which comprises of acute leukemia, Non-Hodgkin's lymphoma, metastatic infiltration and MDS), pancytopenia due to other causes (all infectious causes- Leishmaniasis, hepatitis, hypersplenism, HIV reactive, and single case of hemolytic anemia and single case of drug induced pancytopenia).
The use of LDH in diagnosis of acute myocardial infarction is discouraged due to its non-specificity as its increased levels are found in progressive muscular dystrophy, myoglobinuria, leukemia, pernicious anemia, megaloblastic
and hemolytic anemia, renal disease and in generalized carcinoma.
Most common causes reported in children are aplastic anemia, megaloblastic anemia, infections like malaria, enteric fever, leishmaniasis, Fanconi anemia, malignancies like acute lymphoblastic leukemia and myelodysplasia.
Nutritional anemia, megaloblastic anemia is one of the leading causes of pancytopenia in developing countries.