aplastic anemia

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Synonyms for aplastic anemia

anemia characterized by pancytopenia resulting from failure of the bone marrow

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Key Words: Leukemia, Megaloblastic Anemia, Aplastic Anemia
KEY WORDS: Pancytopenia, Mean corpuscular volume, Megaloblastic anemia, Aplastic anemia.
It is not a disease entity but a triad of findings that may result from a number of disease processes, the important ones of which are myelodysplasia, leukemia, megaloblastic anemia, aplastic anemia, infiltration of bone morrow due to lymphoma and solid tumors.1 Pancytopenia can present with moderate to severe symptoms like anemia manifested by pallor, fatigue and breathlessness on exertion, infections due to neutropenia e.g.
Red blood cell indices help us to classify anemias as microcytic, normocytic, and macrocytic depending on low, normal or high MCV.3 Most of the causes of pancytopenia present with normal RBC indices,4 but causes like megaloblastic anemia, aplastic anemia, myelodysplastic syndrome and paroxysmal nocturnal hemoglobinuria present with high MCV.5
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