Evolutionary selection across the nuclear hormone receptor superfamily with a focus on the NR1I subfamily (vitamin D, pregnane X, and constitutive androstane receptors).
Pregnane X receptor (PXR), constitutive androstane receptor (CAR), and benzoate X receptor (BXR1 define three pharmacologically distinct classes of nuclear receptors.
(197) Specifically, the court found that, although five of eighteen disclosed androstanes were claimed, the specification did not identify which androstanes were useful or what biological properties they possessed:
With respect to the eighteen androstanes that are disclosed, five of which are claimed here, it is said they "are of value...
Effects of estradiol, stilbestrol, and some alkyl-carbonyl androstanes
upon sex differentiation in the medaka, Oryzias latipes.