CHO-K1 cells were stably transfected using the AR and the luciferase reporter gene regulated by the hormone response element (HRE) present in themousemammary tumor virus (MMTV) promoter.The system has a high sensitivity (0.1 nmol/L) for androgens
such as testosterone and can distinguish androgenic and antiandrogenic activities.
It is not clear, however, if the same diagnostic and prognostic criteria should apply to prostate glands subjected to previous androgen
may be called "male hormones," but don't let the name fool you.
(9), (10), (12) Because there is evidence that increased androgens
can promote insulin resistance and that the inverse, hyperinsulinemia may promote hyperandrogenism, it is difficult to know which comes first and highlights the importance of a complete laboratory analysis of all patients presenting with "PCOS-like symptoms" regardless of their weight, as all women with PCOS have an increased risk of developing diabetes later in life.
Since the publication of Huggins work in 1942 , androgen
blockade has been a treatment option for metastastic prostate cancer and for biochemical failure after primary therapy.
Genetic association between androgen
receptor gene CAG repeat length polymorphism and male infertility: a meta-analysis.
receptor, prostate adenocarcinoma, Histopathology.
Acne is one of the commonest dermatological disorders with a prevalence of 22%1 It is a disease of the pilosebaceous follicle with presence in 70-95% of dermatological patients.2 Endocrine mechanisms control the components of sebocyte function-namely lipid synthesis, proliferation and differentiation.3 Androgens
upregulate sebaceous gland function by binding to the nuclear androgen
Ovarian hyperandrogenism/ luteal inadequacy hypothesis,  Grattarola 1960: The risk of breast cancer increases with excess ovarian androgens
, chronic anovulation, reduction of luteal phase progesterone.
However, in recent years, many studies have suggested that androgens
also play an important role in female reproductive organs (Davis, 1999a, b, 2000).
It is important to distinguish the source of androgens
in order to improve the classification, the understanding of androgen
excess disorders, and subsequent management .
Wu, "Effects of cryptotanshinone in lowering androgens
synthesis for the prenatally androgenized male rats," Chinese Journal of Integrated Traditional and Western Medicine, vol.
Acne is actually caused by a blockage of your sebaceous (grease) glands which are entirely under hormonal control, by androgens
, in fact.
In men with advanced prostate cancer, growth of cancer cells depends on androgen
receptor signaling, which is driven by androgens
, such as testosterone.
) and ultimately blocks the action of androgen