Tween-80 and impurity induce anaphylactoid reaction
The likelihood of an anaphylactoid reaction
to contrast media is not necessarily related to contrast media dose, nor is it always an immediate response to contrast media exposure.
Four subjects in the FCM group experienced Grade 1 hypersensitivity reactions, and no subject experienced anaphylaxis or an anaphylactoid reaction
. Based on previous studies conducted on low-molecular-weight iron dextran the rate of anaphylaxis or anaphylactoid reactions
was reported to be 1.7% [10, 11].
Although the hemodynamic changes occurring during anaphylaxis and anaphylactoid reactions
may vary, the major factors causing cardiovascular abnormalities are universal and result from an initial loss of intravascular fluid and vasodilation, which may be followed shortly by vasoconstriction and then myocardial depression.
Symptoms such as urticaria and anaphylactoid reactions
do not stem from true allergic reactions as one would expect after ingesting food or other immune-system-provoking substance.
Anaphylactic or anaphylactoid reactions
may also be secondary to complement activation with liberation of anaphylatoxins.
All iron replacement products have potential life-threatening anaphylactoid reactions
(e.g., hypotension, dyspnea, flushing, and back pain), with iron dextran having the highest risk as compared to the other iron preparations (Fishbane & Shah, 2015; KDIGO Anemia Work Group.
Two patients on resli zumab had anaphylactoid reactions
, neither requiring epinephrine.
Although PE is known to decrease the mortality rate of TTP from 90 percent (prior to the use of PE) to 20 percent, the procedure itself may have adverse reactions, such as pneumothorax, hemorrhage, local and systemic infection at catheter site, venous thrombosis, catheter obstruction, citrate anticoagulant-induced symptoms of hypocalcemia, (paresthesias, muscle cramps, nausea and vomiting, hypotension, and tetany), allergic symptoms including anaphylactoid reactions
, or transfusion-related acute lung injury (TRALI) .
may occur in the absence of IgE, but with similar clinical outcomes.
Causes of anaphylactoid reactions
in cattle after administration of lipoid preparations.
ICG is a popular diagnostic reagent that is clinically approved for use in liver function tests.[sup.15] Several anaphylactoid reactions
to ICG requiring resuscitation were reported in 0.05% of patients,[sup.16] while such reactions to patent blue dye were reported in 0.3% of patients.[sup.17] Our preliminary result was consistent with the previously reported results, and we have never seen adverse effects related to ICG injections.
The largest experience in the published CKD literature is with this formulation, and has shown the best safety profile in terms of severe and/or anaphylactoid reactions
with rates less than 0.06% (Auerbach & Ballard, 2010).
are clinically similar, but are not IgE mediated.
(14) Hypersensitivity reactions can occur, resulting in anaphylaxis (type 1), anaphylactoid reactions
(complement mediated), or delayed serum sickness (type 3), and are treated with a combination of diphenhydramine and epinephrine.