Screening, surveillance, and treatment of anal intraepithelial neoplasia
. Clin Colon Rectal Surg.
A double-blind, randomized controlled trial of the use of imiquimod cream for the treatment of anal canal high-grade anal intraepithelial neoplasia
in HIV-positive MSM on HAART, with long-term follow-up data including the use of open-label imiquimod.
AIN, anal intraepithelial neoplasia
; HTX, heterosexual; IDU; injection drug use; MSM, men who have sex with men; NA, not available; NS, not statistically significant; OR, odds ratio; RR, relative risk; STI, sexually transmitted infection ** Lowered risk.
The pathology and molecular biology of anal intraepithelial neoplasia
: comparisons with cervical and vulvar intraepithelial carcinoma.
Vulvar, vaginal and anal intraepithelial neoplasia
(VIN, VAIN and AIN) appear to be prevalent among HIV-infected women.
samples positive by nPCR Normal ([double dagger]) anogenital/oral swabs 49 18 (37) CD4 [less than or equal to] 200/[micro]L 18 6 (33) CD4 >200/[micro]L 31 12 (39) Anal 20 6 (30) Penile 6 3 (50) Oral 23 9 (39) Benign papilloma/acanthoma 21 6 (29) Anal 12 4 (33) Penile 6 2 (33) Oral 3 0 (0) Dysplasia/carcinoma in situ 43 12 (28) Anal intraepithelial neoplasia
27 7 (26) Penile intraepithelial neoplasia 14 4 (29) Oral carcinoma in situ 2 1 (50) Anal cancer 7 1 (14) All anal, penile, or oral samples 120 37 (31) CD4 [less than or equal to] 200/[micro]L 45 13 (29) CD4 >200/[micro]L 75 24 (32) Plucked eyebrow hairs 14 7 (50) Cerebrospinal fluid 7 0 (0) No.
Compari son of patient- and clinician-collected anal cytology samples to screen for human papillomavirus-associated anal intraepithelial neoplasia
in men who have sex with men.
CHICAGO -- Routine screening for anal intraepithelial neoplasia
could pick up missed cancers, Dr.
Several single-center studies in the combination antiretroviral therapy era have assessed the power of abnormal anal cytology to predict anal intraepithelial neoplasia
(AIN) or other outcomes (Table 2).
Given the current recommendation of utilizing the HPV vaccine for the prevention of HPV-associated anal intraepithelial neoplasia
in certain groups, such as MSM (13,14,15), and in this time in which no national guidelines exist regarding recommendations for routine anal cancer screening (16), it is important to document the burden of anal cancer in both men and women in this Hispanic population.
The LSIL finding was designated as the all-encompassing term for CIN 1, vaginal intraepithelial neoplasia 1 (VaIN 1), vulvar intraepithelial neoplasia 1 (VIN 1), penile intraepithelial neoplasia 1 (PeIN 1), perianal intraepithelial neoplasia 1 (PAIN 1) and anal intraepithelial neoplasia
1 (AIN 1).
P16/CDKN2A and Ki-67 enhance the detection of anal intraepithelial neoplasia
and condyloma and correlate with human papillomavirus detection by polymerase chain reaction.