ISLAMABAD -- Excessive daytime sleepiness in cognitively normal elderly leads to a build-up of a plaque in the brain called amyloid
said a study published in the journal JAMA Neurology.
It's exciting to see that the amyloids
can hold more than their own mass in heavy metal particles, Li says.
Human islet amyloid
polypeptide (hIAPP) or amylin is a 37-residue peptide hormone secreted from [beta]-cells within the islet of Langerhans in the pancreas.
To find out if amyloids
can behave like enzymes too, Korendovych and his team designed seven simple peptides that were made from seven amino acids.
The test provides an accurate diagnosis by identifying even small quantities of amyloid-beta clusters- the toxic proteins responsible for Alzheimer's disease- present in the blood stream, and differentiating them from the individual amyloid
proteins found in healthy people.
"Now we have a chemical target to research further and help us investigate what could be the underlying biological cause of heart failure and if it is like Alzheimer's, an amyloidrelated disease." The new research raises the prospect of treating the root cause of heart failure by preventing the formation of desmin amyloids
, said Dr Agnetti.
We report 2 cases of laryngeal amyloidosis in which dense plasma cell infiltrates were found in the vicinity of the amyloid
deposits; in view of this finding, we suspected a hematologic disease--plasmacytoma in particular.
Westermark, "Localized amyloids
important in diseases outside the brain--lessons from the islets of Langerhans and the thoracic aorta," The FEBS Journal, vol.
(1-42), a major component of amyloid
plaques, accumulates in neurons of Alzheimer's disease (AD) brains.
hypothesis isn't dead, but it seems to be limping a bit in the race for an Alzheimer's cure.
Smith, who is a paid consultant for several companies investigating non-amyloid related therapies, is among a minority of researchers who resist the amyloid
theory, although the overwhelming focus on amyloid
has virtually drowned their opinion.
hypothesis is not dead, but it seems to be limping a bit in the race for an Alzheimer's cure.
Amyloidosis in humans was first recognized in the mid-19th century when Rudolf Virchow coined the term amyloid
(for starch or cellulose) to describe abnormal extracellular material seen in the liver at autopsy. In fact, he was mistaken about the nature of the material, since all amyloid
deposits characterized to date have been shown to consist predominantly of protein not carbohydrate.