R-Secretase cleavage of Alzheimer's amyloid precursor protein
by the transmembrane aspartic protease BACE.
PKC inhibits the [beta] secretase that forms the toxic A[beta] from the amyloid precursor protein
40) (b) Genetic defect in proteins involved in the inflammatory response but not the amyloid precursor protein
Merck (NYSE: MRK), known as MSD outside the United States and Canada, and GE Healthcare today announced a clinical study collaboration, license and supply agreement for use of [18F]Flutemetamol, an investigational positron emission tomography (PET) imaging agent, to support Merck's development of MK-8931, a novel oral beta amyloid precursor protein
site cleaving enzyme (BACE) inhibitor and Merck's lead investigational candidate for Alzheimer's disease (AD).
PS1 is believed to function as the "gamma secretase" that cleaves amyloid precursor protein
to yield beta-Amyloid (A [beta]) peptides.
The study revealed that loss of NEU1 activity was linked with a build-up in lysosomes of the amyloid precursor protein
(APP) that they identified as a natural target of the enzyme.
It has been shown that early-onset AD, accounting for about 5% of total AD cases, afflicts people at the age of 30 to 60, and is mainly caused by mutations of tree genes coding for the amyloid precursor protein
(APP) and presenilin 1/2 on chromosomes 21, 14, and 1, respectively.
A first step to accumulating beta amyloid is the production of amyloid precursor protein
The purpose of this study was to investigate whether repeated electroacupuncture (EA) stimulation would improve cognitive function and the pathological features of AD in amyloid precursor protein
(APP)/presenilin 1 (PS1) double transgenic mice.
Normal and Pathogenic Cleavage of Amyloid Precursor Protein
The research team has found that white blood cells in the circulating blood, called peripheral blood mononuclear cells express amyloid precursor protein
That receptor may be sensitive to a secreted version of amyloid precursor protein
, says Kosik.
Amyloid Precursor Protein
, APP, is predominantly processed by a-Secretase, producing a 83-amino acid C-terminal fragment, C83; while a small amount is processed by b-Secretase, producing a 99-amino acid C-terminal fragment, C99.
seek to use YACs to give mice an extra gene for amyloid precursor protein
AB peptides are "cut" out from a larger protein called the amyloid precursor protein
(APP) by an enzymatic "scissor" called B-secretase, and aggregate to form plaques in the brain regions responsible for memory.