Vassar R, Bennett BD, Babu-Khan S, Kahn S, Mendiaz EA, Denis P Beta-secretase cleavage of Alzheimer's amyloid precursor protein
by the transmembrane aspartic protease BACE.
Avadhani, "Mitochondrial targeting and a novel transmembrane arrest of Alzheimer's amyloid precursor protein
impairs mitochondrial function in neuronal cells," The Journal of Cell Biology, vol.
Calcium-mediated transient phosphorylation of tau and amyloid precursor protein
followed by intraneuronal amyloid-beta accumulation.
PKC activates the alpha secretase that forms the positive, synaptogenic soluble amyloid precursor protein
, sAPPa, from the amyloid precursor protein
Beta secretase, a protease that cleaves amyloid precursor protein
and results in toxic [beta]-amyloid peptides, may also be upregulated by inflammatory mediators.
40) (b) Genetic defect in proteins involved in the inflammatory response but not the amyloid precursor protein
The invention also provides the pentapeptide Ser-Met-Arg-Glu-Arg, corresponding to residues 332 to 328 of human amyloid precursor protein
in reverse order, and the tripeptide Arg-Glu-Arg which corresponds residues 328 to 330 of human amyloid precursor protein
, the tripeptide and pentapeptide being provided as pharmaceutical compositions.
The function of the amyloid precursor protein
(APP) is unclear.
Other topics of the 12 contributions include signal transduction pathways leading to caveolin tyrosine phosphorylation, lipid rafts in the trafficking of prion protein and amyloid precursor protein
, and the role of careolin-1 in tumor cell survival and cancer progression.
Nasser Zawia, an associate professor of pharmacology and toxicology at the University of Rhode Island, Kingston, and his colleagues found increased expression of amyloid precursor protein
(APP) and its product, [beta]-amyloid (which is a hallmark of Alzheimer disease), in aging rats that were exposed to lead shortly after birth.
Yu and his colleagues discovered that nicastrin binds to several proteins lodged in the cell's membrane, including one called amyloid precursor protein
, or APP.
Although researchers still don't know for sure what causes Alzheimer's disease, most believe it is related to the abnormal processing of normal brain proteins, particularly amyloid precursor protein
and tau, another type of protein.
Then we discovered that HSV particles moving in the anterograde direction are associated with cellular amyloid precursor protein
PS1 is believed to function as the "gamma secretase" that cleaves amyloid precursor protein
to yield beta-Amyloid (A [beta]) peptides.
A kindred with autosomal dominant familial Alzheimer's disease in which a mutation results in a valine to glycine substitution at amyloid precursor protein
codon 717 has recently been described.