Proteolytic processing and cell biological functions of the amyloid precursor protein
. J Cell Sci 2000;113:1857-1870.
MicroRNA-193b is a regulator of amyloid precursor protein
in the blood and cerebrospinal fluid derived exosomal microRNA-193b is a biomarker of Alzheimer's disease.
"A mutation in the amyloid precursor protein
associated with hereditary Alzheimer's disease," Science, 254(5028), 97-99.
Morris water maze probe trial parameters of amyloid precursor protein
transgenic mice (Tg) and age-matched wild-type littermates (WT) (n=16/group).
Beyreuther, "Amyloidogenic processing of the human amyloid precursor protein
in primary cultures of rat hippocampal neurons," Journal of Neuroscience, vol.
Elevated vulnerability to oxidative stress-induced cell death and activation of caspase-3 by the Swedish amyloid precursor protein
(35.) Vassar R, Bennett BD, Babu-Khan S, Kahn S, Mendiaz EA, Denis P Beta-secretase cleavage of Alzheimer's amyloid precursor protein
by the transmembrane aspartic protease BACE.
Finally, three end products are formed (sAPP-[beta], A[beta], and amyloid precursor protein
intracellular domain, AICD).
People with Down syndrome are born with an extra copy of chromosome 21, which contains the amyloid precursor protein
Molecular evidences show that HSV-1 infection of neuronal and glial cells results in the formation of the characteristic abnormal molecule of AD ([alpha]-amyloid) and a decrease of the amyloid precursor protein
Cleavage of the amyloid precursor protein
(APP) generates varying lengths of A3 peptides (38-43 amino acids) that accumulate in the extracellular space.
Amongthe clumpy proteins Buhimschi and her colleagues discovered in the urine was amyloid precursor protein
, or APP, a protein that, when cleaved into fragments, forms plaques in the brains of people with Alzheimer's.
It degrades various substrates such as insulin, IGF-II, TGF-?, glucagon, amylin, calcitonin, ?-amyloid and amyloid precursor protein
The collaboration will initially involve the co-development and commercialization of Eisai's two candidates: E2609, a [beta]-site amyloid precursor protein
cleaving enzyme (BACE) inhibitor, and BAN2401, an anti-A[beta] antibody.
The purpose of this study was to investigate whether repeated electroacupuncture (EA) stimulation would improve cognitive function and the pathological features of AD in amyloid precursor protein
(APP)/presenilin 1 (PS1) double transgenic mice.