Sandrock: The presence of amyloid plaques
is a pathological hallmark of Alzheimer's disease.
We have determined that the G protein-coupled receptor 3, a protein which also found in the brain, is responsible for the production of amyloid-beta peptides and the aggregation of amyloid plaques
," said Thorsson.
Laureate Professor Colin Masters, from the University of Melbourne and the Florey Institute, said scientists believed the presence of amyloid plaques
was a key reason some people developed Alzheimer's, a debilitating brain condition which affects memory.
For this study, the team used the tracer molecules PIB, Deprenyl and FDG to study the amount of amyloid plaques
, inflammatory changes in the form of astrocyte activation, astrocytes being the most common type of glial (supporting) cell in the brain.
Blocking steps known to be essential for the formation of amyloid plaques
also prevented the formation of the tangles, confirming amyloid's role in initiating the process.
All had their brains scanned using a tracer chemical that binds with amyloid plaques
so that they show up on the images.
Klunk was a member of the team that invented Pittsburg Compound B (PiB), the first radioligand used to examine amyloid plaques
in living brains.
In unraveling oligomers' molecular structure, Guo and colleagues discovered that A[beta] has a vastly different organization in oligomers than in amyloid plaques
Complete regression of amyloid plaques
in middle aged mice and significant reduction of plaques in the cortex and hippocampus of old mice were reported at the end of the study.
Scientists have linked poor sleep with a build up of amyloid plaques
- sticky clumps of protein that build up in the brain which are a hallmark of Alzheimer's disease.
The investigational drug removed amyloid plaques
, one of the disease's main features, from the brains of the patients.
The major pathologic findings in the AD brain at autopsy are amyloid plaques
(extracellular), neurofibrillary tangles (intracellular), and the loss of synaptic connections.
This elegant study illustrates that amyloid plaques
are only a component of the disease process in Alzheimer's disease, in that that there are many people who have the plaques but not the disease.
It is believed to stop the spread of amyloid plaques
that damage the wiring in the brain and lead to Alzheimer's and other forms of dementia.
Scientists have long questioned whether the abundant amounts of amyloid plaques
found in the brains of patients with Alzheimer's actually caused the neurological disease or were a by-product of its progress.