Arterial stiffness was highest in people who had both amyloid plaques
and white matter hyperintensities in the brain, or brain lesions.
At the end of the treatment they found that this drug, by blocking the 5-lipoxygenase, reduced gamma secretase's production of amyloid beta and the subsequent build up of amyloid plaques
in the brain by more than 50 percent.
Trials of two new [sup.18]F imaging compounds have demonstrated the agents' ability to bind to amyloid plaque
, revealing their potential to detect the buildup of amyloid over time in patients who develop or have progression of cognitive impairment and to differentiate Alzheimer's disease from other types of dementia.
15, 2010 issue of the Journal of Neuroscience found that these people may experience changes in the way the brain's default mode network is connected, even though there is no presence of amyloid plaques
. When you daydream or relax without concentrating on a particular task, the default mode network generates spontaneous thoughts and is considered to be a crucial part of creativity.
London, February 21 ( ANI ): A research team including an Indian origin has identified a new gene associated with the amyloid plaque
deposits found in Alzheimer's disease patients.
He and his colleagues added microglia to slices of rodent brain tissue riddled with amyloid plaques
. The immune cells took up the amyloid, but only if the researchers also introduced antibodies that bind to beta-amyloid.
Currently, Alzheimer's disease can only be definitively confirmed through the detection of amyloid plaques
and/or tangles in the brain during autopsy after death or with a brain tissue biopsy.
Many scientists, but not all, believe that these amyloid plaques
kill or damage brain cells, producing memory loss and other symptoms of the illness.
"Disrupted sleep appears to be associated with the build-up of amyloid plaques
, a hallmark marker of Alzheimer's disease, in the brains of people without memory problems," said study author Yo-El Ju, MD, with Washington University School of Medicine in St.
Researchers at MGH have found evidence of long-term degenerative changes in the brains of older adults who are cognitively normal, but who show signs of the formation of amyloid plaques
(clumps of toxic proteins that are a hallmark of Alzheimer's disease (AD).
"This is the first time that anyone has stopped the development of amyloid plaques
in a mouse model of Alzheimer's," says Marcelle Morrison-Bogorad of the National Institute on Aging in Bethesda, Md.
On January 20, 2011, an advisory committee to the Food and Drug Administration (FDA) recommended approval of the chemical Amyvid (florbetapir) for use in the detection of beta amyloid plaques
(collections of brain protein fragments) that are the hallmark of Alzheimer's disease (AD).
Some researchers have suggested that an accumulation of amyloid plaques
over many years contributes to Alzheimer's disease, which would help explain why the condition usually strikes the elderly.
and neurofibrillary tangles in the brain have been considered the hallmarks of Alzheimer's disease (AD).
In shape and size, the new lesions, labeled AMY plaques, often resemble the disease's characteristic amyloid plaques
, and they almost never appear in brains devoid of the amyloid plaques