Light brown amorphous solid
; Yield: 92 %; m.p: 129-131 AdegC; Mol.
Demuth et al., "High speed electrospinning for scaled-up production of amorphous solid
dispersion of itraconazole," International Journal of Pharmaceutics, vol.
The excess phloroglucinol was precipitated out using dichloromethane to obtain the required product 19a in good yield (44.6 mg, 66%) as a light brown amorphous solid
. IR (KBr, v/[cm.sup.-1]): 1724 (C=O) and 1593 (aromatic C=C stretch).
Copolymer alpha-cyclodextrin (POLYA) was synthesized as described in [14, 15] and an amorphous solid
dispersion (ASD) of cyclosporine was prepared using the spray-dried dispersion method described by Boukhris et al.
Compound 2 coded as [W.sub.8]A (14 mg), was obtained as yellow amorphous solid
and minor constituent with [R.sub.f] value of 0.48 in EtOAc-MeOH (4:1).
These vibrations are characteristic of a carbonate groups engaged in an amorphous solid
. The amorphous solid
had a strong band at 1060, 570 and 606[cm.sup.-1] which were associated to the P-O vibration modes respectively.
This material, called amorphous solid
water (ASW), appeals to scientists interested in liquids because the molecules in it move extremely slowly, which makes them relatively easy to examine.
"Hovione has a unique value proposition when it comes to processing amorphous solid
Solanoid A (1): white amorphous solid
; IR (KBr) max 3430, 3045 and 1626cm-1; 1H NMR (CD3OD, 600 MHz) and 13C NMR (CD3OD, 150 MHz) data are provided in Table-1; HR-FAB-MS m/z 704.4351 [M-H]- (calcd.
The traditional picture [17, 18] viewed the TS, present in low concentration (~[10.sup.16] [g.sup.-1]) in the material, associated with the nonequivalence of two (or more) bonding-angle configurations per atomic unit in the amorphous solid
's atomic structure.
PLASTIC IS the general common term for a wide range of synthetic or semi synthetic organic amorphous solid
materials suitable for the manufacture of industrial products.
The bandwidth at 1725 [cm.sup-1] in the amorphous solid
is higher than in the crystallized sample.
Compound 2 was isolated as amorphous solid
having triterpenoidal structure as indicated by positive Liebermann-Burchard test.
Spray drying enables creation of amorphous solid
dispersions (ASDs) of poorly soluble drugs using a large array of excipients that can be chosen to optimize performance.