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The increase in serum and brain serotonin levels of rabbit administered sertraline, clozapine, imipramin and amitryptyline drugs may promote serotonin synthesis in the brain.
The tricyclics, notably amitryptyline and imipramine are frequently implicated (69).
Amitryptyline (Elavil[R]), clomipramine (Anafranil[R]), and imipramine (Tofranil[R]) are the older tricyclic antidepressants.
Amitryptyline was moderately efficacious in 3 small nonblinded trials.
Dinan T, Mobayed M: Treatment resistence of depression after head injury: A preliminary study of amitryptyline response.
The Fatality Index (FTI) ranks amitryptyline (a TCAD) and tranylcypromine as the two highest-ranking drugs with "unacceptable risks" of [greater than] 40 deaths per million prescriptions per year.