EVALUATING THE INTERACTIONS BETWEEN AMINOACYL-tRNA
SYNTHETASES AND ELONGATION FACTOR TU IN PROTEIN SYNTHESIS
Therefore, one would expect to observe the impaired translation of an abundant mRNA species containing an excess of rare codons with low aminoacyl-tRNA
These viruses, because of their size, the complexity of their genome that harbors three genes for aminoacyl-tRNA
synthetases described for the first time in a viral genome and four unique orphan genes, challenges the definition of viruses and even the definition of an organism (Raoult & Forterre 2008).
The enzyme that catalyzes this amino acid-RNA attachment is the aminoacyl-tRNA
Autoantibodies against aminoacyl-tRNA
synthetase: novel diagnostic marker for type 1 diabetes mellitus.
Cabanas MJ, Vazquez D, and Modolell J: Dual interference of hygromycin B with ribosomal translocation and with aminoacyl-tRNA
Directed at new researchers without the benefit of a couple of decades of work in the field, this explains the initial work of Selman Waksman to produce streptomycin, then proceeds to such topics as the biochemistry and genetics of aminoglycoside producers, mechanics of aminoglycoside antibiotic resistance, the development and action of kanamycin and neomycin class antibiotics, NMR structural studies and RNA interaction, structural comparisons between prokaryotic and eukaryotic ribosomal decoding, binding of antibiotics to the aminoacyl-tRNA
site of bacterial ribosome, the chemistry and biological relevance of metalloaminoglycosides, adverse effects of aminoglycoside therapy, new efforts at targeting HIV-1 RNA, and novel targets for aminoglycosides.
Cubist received the milestone payment for developing and transferring technology enabling Bristol-Myers Squibb to target specific aminoacyl-tRNA
To illustrate the power of matching against secondary structure predictions, we present a novel proposed protein alignment, found using this system, for the protein class of aminoacyl-tRNA
Binding of Antibiotics to the Aminoacyl-tRNA
Site of Bacterial Ribosome (Dale Kling, Christine Chow, and Shahriar Mobashery).
In the GTP-bound form of the molecule, EF-Tu binds tightly to aminoacyl-tRNA
, forming a ternary complex that interacts with the ribosomal acceptor site.
13: Bioisosteric relationship between puromycin and aminoacyl-tRNA
Antibacterial activity will be achieved through inhibition of essential aminoacyl-tRNA
Stimulatory effect of genistein and daidzein on protein synthesis in osteoblastic MC3T3-E1 cells: activation of aminoacyl-tRNA
Recent study results have suggested that Hcy-induced vascular damage could be a result of Hcy-thiolactone (HcyT), an Hcy-reactive product formed in several cell types as a result of editing reactions of some aminoacyl-tRNA
synthetase (5, 6).