(*) p<0.05, (**) p<0.01, (***) p<0.001 Metabolic pathway Pathway name category Carbohydrate metabolism pantothenate and CoA metabolism TCA cycle glyoxilate and dicarboxylate metabolism Amino acid metabolism glycine, serine and threonine metabolism, alanine, aspartate and glutamate metabolism Valine, leucine and isoleucine me metabolism cysteine and methionine metabolism Genetic information processing aminoacyl-tRNA
biosynthesis Energy metabolism Methane metabolism Metabolic pathway Metabolite matehes category Carbohydrate metabolism Pantothenate, Valine Succinate, Pyruvate Glycolate, Citrate Amino acid metabolism Serine, Choline, Glycine, Betaine, Pyruvate Alanine.
This study found 10 potential biomarkers (1,5-anhydroglucitol, [alpha]-hydroxyvaleric acid, galactose glucitol, phenylalanine, glutamic acid, L-isoleucine, phenylpropionic acid, Nacetylglycine, ornithine, and lysine) and six metabolic pathways (alanine, aspartate, and glutamate metabolism, arginine and proline metabolism, lysine degradation, phenylalanine metabolism, aminoacyl-tRNA
biosynthesis, D-glutamine, and D-glutamate metabolism) can be used to discriminate infertile males with KYDS from healthy controls.
Based on our KEGG pathway analysis, the most enriched pathways corresponding to the differentially expressed lncRNAs were associated with lysosome, RNA transport, and aminoacyl-tRNA
biosynthesis (Figure 2(b)) (Supplementary Table 7).
[20.] Masayoshi Yamaguchi, Hidetoshi Oishi and Yasunobu Suketa, Zinc stimulation of bone protein synthesis in tissue culture: Activation of aminoacyl-tRNA
synthetase, Biochemical Pharmacology, 37 (21), 4075-4080 (1988).
Phosphorylation of aminoacyl-tRNA
synthetases could play a role in the regulation of protein synthesis in a similar manner as insulin regulates muscle (Kimball et al., 1994).
The correct amino acid is attached to each tRNA species by specific enzymes called aminoacyl-tRNA
The full-length protein containing the unnatural amino acid could be produced when the four-base codon is successfully decoded by the unnatural aminoacyl-tRNA
having the corresponding four-base anticodon.
Protein synthesis relies on 20 canonical amino acids encoded accordingly to a genetic code, each codon being recognized by an aminoacyl-tRNA
. The molecular basis of the genotype to phenotype correspondence relies on the conjunction of tRNAs and of aminoacyl-tRNA
It catalyzes the esterification of a specific synthetase (AARS) amino acid or its precursor to one of all its compatible cognate tRNAs to form an aminoacyl- tRNA.
9:30 INVESTIGATING TRNA CHANNELING BY AMINOACYL-TRNA
SYNTHETASES AND ELONGATION FACTOR TU
constitutes a family of RNA-binding proteins, that is, responsible for the correct translation of the genetic code by covalently linking the appropriate amino acid to the 3' end of the correct tRNA.
Separately, a 3-chlorotyrosinecharged tRNA containing a CUs anticodon, was prepared by a combination of chemical synthesis and enzymatic ligation, followed by aminoacylation of 3-chlorotyrosine using an aminoacyl-tRNA
These viruses, because of their size, the complexity of their genome that harbors three genes for aminoacyl-tRNA
synthetases described for the first time in a viral genome and four unique orphan genes, challenges the definition of viruses and even the definition of an organism (Raoult & Forterre 2008).
Therefore, one would expect to observe the impaired translation of an abundant mRNA species containing an excess of rare codons with low aminoacyl-tRNA