To determine whether the peptide bond or the
amino acid residue of silk peptide is responsible for the co-initiating function, we investigated the photo-initiating ability of four essential amino acids of silk peptide, glycine, alanine, serine, and tyrosine, as well as of four pentapeptides synthesized using these amino acids as substrate, respectively.
Molecules that contain sugar units linked to amino acids or
amino acid residues through carbon carbon sigma bond termed as C-glycopeptoid.
Thus, the docking site was composed of
amino acid residues located 8 [Angstrom] from the central point.
All, including the very recent ones, concluded that the nature of
amino acid residues in aa position 70 of HCV core can help to distinguish patients who can still benefit from the affordable IFN-based therapy from those who must be treated with DAAs to prevent the evolution towards the end-stage liver disease [25].
([section])
Amino acid residue 134 in influenza type B NA corresponds to residue Q136 in N1 and N2 NA amino acid numbering (6).
[alpha]-Synuclein consists of 140
amino acid residues [24] organized in three structural regions: an amphipathic amino-terminal domain from 1 to 60
amino acid residues, responsible for the binding of [alpha]-synuclein to lipid vesicles [25, 26]; the NAC (non-amyloid-[beta] component) region from 61 to 95
amino acid residues, also found in amyloid plaques of patients suffering from Alzheimer's disease [27] and responsible for [alpha]-synuclein aggregation and [beta] sheets arrangement [28]; and the carboxy-terminal domain from 96 to 140
amino acid residues, which is the main target for the protein phosphorylation [29, 30] (Figure 1(a)).
Most are cationic and amphipathic containing a significant number of positively charged and hydrophobic
amino acid residues; often the C-terminus is amidated effectively removing a membrane-repelling negative charge and replacing this with a hydrophobic membrane-interacting group; those that display antifungal activity often contain a high proportion of polar neutral
amino acid residues [7-9].
Each structure is abstracted to a collection of points in three-dimensional (3D) space, corresponding to the C-alpha coordinates of all its constituent
amino acid residues (i.e., coarse graining of the protein structure at the residue level).
In BIB regions 3/10 helices are usually separated from both beta strands by a single
amino acid residue (see Figures 3(a) and 3(c)).
However, the most notable difference is at
amino acid residue 52.
Therefore, in order to evaluate the functional contribution of particular
amino acid residue to inhibition, alanine scanning experiments were performed on these inhibitor proteins, with a focus on the region containing the cysteine residue or homologous region (Tables 1 and 2).
Glycine is the smallest
amino acid residue, devoid of side, and is flexible which aids in relaxation of steric hindrance of thermophilic enzymes and increases stability [42].
Replacement of a proline
amino acid residue by aspartic acid disrupts an important interaction between monomer peptide chains, allowing rapid dissociation of hexamers and dimers into monomers.
LHR I and LHR II motif were found at the
amino acid residue positions 289-293 and 462-517 of the translated polypeptide sequences.
An
amino acid residue is that part of an amino acid that is not incorporated into the peptide bond or protein chain.
