SSAO, also known as VAP-1 (Vascular Adhesion Protein-1), is a dual-function amine oxidase
which increases oxidative stress through the generation of H2O2 and promotes recruitment of white blood cells in the liver, which results in increased oxidative stress, inflammation and hepatic fibrosis.
Hepatic microsomal mixed-function amine oxidase
. Methods Enzymol.
This is an emerging role for the LOX family of secreted copper-dependent amine oxidases
, whose primary function is the covalent crosslinking of collagens and/or elastin in the extracellular matrix, maintaining tissue strength and structural integrity .
The report provides comprehensive information on the Lysine-Specific Histone Demethylase 1A (Lysine (K)-Specific Demethylase 1 or Flavin-Containing Amine Oxidase
Domain-Containing Protein 2 or EC 1.), targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type.
Various oximes have been shown to inhibit copper-containing amine oxidases
due to their interaction with the enzyme-bound cupric ions .
Ab, "Cloning and sequencing of the peroxisomal amine oxidase
gene from Hansenula polymorpha," Biochimica et Biophysica Acta, vol.
The amine oxidase
of the fungi Aspergillus niger has also been reported to be inactivated during the reaction with an analog of the substrate (bromo-ethylamine), and its reaction mechanism was elucidated by analysis of the materials resulting from its suicide inactivation.
Sensitive amperometric biosensor for the determination of biogenic and synthetic amines using pea seedlings amine oxidase
: a novel approach for enzyme immobilisation.
29 October 2010 - Finnish pharmaceutical company Biotie Therapies (HEL: BTH1V) and Swiss drugmaker Roche Holding AG (VTX: ROG) have agreed to end their research and option agreement for the development of small molecule inhibitors of semicarbazide-sensitive amine oxidase
(SSAO), Biotie said today.
The recent introduction of new investigative technology has produced a wealth of new information about copper amine oxidase
proteins (CAOs), including their involvement in both healthy cells and in clinical manifestations associated with a wide variety of diseases.
falvinflavin containing domain 2 (AOF2)
Internet rumours claim Mr Brown is taking mono amine oxidase
inhibitors - an alternative to Prozac.
"We are now identifying microbes with a type of enzyme called an amine oxidase
. This could be key to cheaper, more efficient and sustainable process in the synthesis of valuable chemicals by both the pharmaceutical and agrochemical industries," he added.
Similarly copper binding proteins, potentate amino acid metabolism, by having a functional role in two biological processes, namely amine oxidase
and oxidoreductase activity.
Pea seedlings amine oxidase
(PSAO) has been found to have a 100% relative specific activity towards 1,4-diaminobutane, 111% towards 1,5-diaminopentane, 56% towards agmatine and spermidine, 44% towards 1,6-diaminohexane, 30% towards histamine, 8% towards spermine, and no activity towards 1,3-diaminopropane .