The report provides comprehensive information on the Lysine-Specific Histone Demethylase 1A (Lysine (K)-Specific Demethylase 1 or Flavin-Containing Amine Oxidase
Domain-Containing Protein 2 or EC 1.
Activity Measurement by Fluorometric Determination of Hydrogen Peroxide.
Various oximes have been shown to inhibit copper-containing amine oxidases
due to their interaction with the enzyme-bound cupric ions .
The amine oxidase
of the fungi Aspergillus niger has also been reported to be inactivated during the reaction with an analog of the substrate (bromo-ethylamine), and its reaction mechanism was elucidated by analysis of the materials resulting from its suicide inactivation.
Similarly copper binding proteins, potentate amino acid metabolism, by having a functional role in two biological processes, namely amine oxidase
and oxidoreductase activity.
from pea seedlings is reported to belong to the second group .
There are four types of anti-depressants: Tricyclics, such as Tryptizol (the cheapest, as you'll see from our guide on the right) and Anafranil; Mono amine oxidase
inhibitors (MAOIs), such as Nardil and Parnate; Selective Serotonin Reuptake Inhibitors (SSRIs) such as Prozac and Lustral (the most expensive); and Serotonin and Noradrenaline Reuptake Inhibitors (SNRIs), such as Efexor.
A Some anti-depressants called Mono Amine Oxidase
inhibitors react violently with foods like cheese, Marmite or red wine containing the chemical Tyramine and none should be taken with alcohol.
enzymes offer a striking illustration.
The gene responsible for synthesizing DAO is amiloride binding protein 1 (ABP1), also known as amine oxidase
, copper containing 1 (A0C1).
The copper-containing amine oxidases
(monoamine oxidase, semicarbazide-sensitive amine oxidase
, histamine deaminase, amine oxygen oxidoreductase) are ubiquitous metalloenzymes as they have several essential functions in the metabolism of primary amines.
Acrolein is the principal cytotoxic metabolite of the anticancer and arthritis drug cyclophosphamide and is the principal and most physiologically active metabolite of allylamine (15), which is metabolized intracellularly to acrolein via semicarbazide sensitive amine oxidase
In developing the biosensor, they used the enzymes diamine oxidase, monoamine oxidase and plasma amine oxidase
as the specific biological recognition compounds in a continuous flow system.
Carpene and coworkers illustrated that some phenolic compounds did not clearly block amine oxidases
(AO) activities, whereas they impaired the interaction between hydrogen peroxide and the chromogenic mixture in fluorometric assays, which could be misinterpreted as an AO inhibition.
A key scientific target is the realisation of intelligent electronic devices which respond to biomolecules such as formaldehyde, amines, metal ions, saccharides, activities of amine oxidases
, arginase and glutathione-S-transferase.