The companies believe that PT-141 will benefit from the success King has achieved in marketing Altace
(ramipril), the leading branded ACE (angiotensin converting enzyme) inhibitor according to IMS America prescription data, to a similar male patient population with its experienced sales force.
Nicole Chase, 71, of Eugene, said she saves about 50 percent by buying Altace
, a high blood pressure medication, from Canada.
I tracked down an HMO that used Irvin despite his shameless interest in his patients' well-being, so Irvin was able to prescribe Altace
to lower my blood pressure, except my new HMO drug plan won't pay for Altace
but would pay for a similar drug that also worked but which made me cough.
ACE inhibitors include Lotensin, captopril, enalapril, Monopril, Prinivil/Zestril, Univasc, Aceon, Accupril, Altace
Clinical data and interviewed thought leaders also indicate that the regimen of aspirin (Bayer's Aspirin, generics) plus ticagrelor (AstraZeneca's Brilinta/Brilique) plus atorvastatin (Pfizer's Lipitor, generics) plus metoprolol (AstraZeneca's Toprol, Novartis's Lopressor, generics) plus ramipril (Pfizer's Altace
, Sanofi's Triatec, AstraZeneca's Vesdil, generics) has advantages on the attribute of reduced incidence of mortality over the sales-leading regimen for post-myocardial infarction--aspirin plus clopidogrel (Bristol-Myers Squibb/Sanofi's Plavix/Iscover, generics) plus atorvastatin plus metoprolol plus ramipril.
These include ACE inhibitors, such as Altace
(ramipril), and angiotensin II receptor antagonists, such as Diovan (valsartan).
It has been concentrating on developing new painkillers since its top-selling blood-pressure pill Altace
went generic in 2007.
King is trying to shift into pain drugs to compensate for declining sales of its top-selling blood-pressure pill Altace
, which lost patent protection from lower-cost generic versions last year.
A generic version of Altace
will not become available in 2006.
Bristol, TN) and SkyePharma PLC (London, England) announced that they have entered into a licensing agreement for the purpose of developing and commercializing a modified-release formulation of King's product Altace
(ramipril) utilizing SkyePharma's patented oral drug delivery technology Geomatrix.
Comments: Approval was based on the Heart Outcomes Prevention Evaluation (HOPE) multinational study, which compared 10 mg of Altace
a day to placebo in 9,297 men and women at high risk of cardiovascular events due to evidence of vascular disease or diabetes and one other cardiovascular risk factor.
At the initial appointment, he was taking Altace
, atenolol and hydrochlorothiazide to control hypertension.
The company, whose second-quarter earnings plunged as generic competition eroded sales of its blood pressure drug Altace
, said earlier this year that it expects to file for U.
One-Third of Surveyed Payers Identify Altace
as the Most Efficacious Therapy for Diabetic Nephropathy, According to Findings from Decision Resources