Detection of alpha-thalassemia
in beta-thalassemia carriers and prevention of Hb Bart's hydrops fetalis through prenatal screening.
Molecular spectrum of alpha-thalassemia
in the Iranian population of Hormozgan: three novel point mutation defects.
Rodrigues et al., "Association of alpha-thalassemia
, TNF-alpha (-308G>A) and VCAM-1 (c.1238G>C) gene polymorphisms with cerebrovascular disease in a newborn cohort of 411 children with sickle cell anemia," Blood Cells, Molecules & Diseases, vol.
Single-tube multiplex-PCR screen for common deletional determinants of alpha-thalassemia
. Blood 2000;95(1):360-362.
Prevalence and molecular characterization of alpha-thalassemia
syndromes among Indians.
Its products include alpha-thal scan, rapid diagnostic test for alpha-thalassemia
; sickle scan, rapid diagnostic test for sickle cell disease and trait; and hemo scan, a quantitative hemoglobin concentration meter.
Thalassemias (Table 1) typically result in the development of microcytic and hypochromic anemia (NAOUM, 1999), while alpha-thalassemia
has been reported as the most common heritable change of the abnormal hemoglobin synthesis.
Ghosh, "Prevalence and molecular characterization of alpha-thalassemia
syndromes among Indians," Genetic Testing, vol.
is a widespread genetic disorder throughout the world caused primarily by reduced synthesis of the [alpha]-globin chains, and it has been found at a high incidence in Turkey (3), (4).
Other diseases of connection to Sephardi origin include: Alpha-Thalassemia
, Ataxia Telangiectasia, Corticosterone Methyloxidase Type II Deficiency, Costeff Optical Atrophy, Cystic Fibrosis (CF), Familial Creutzfeldt-Jakob Disease, Familial Tumoral Calcinosis (Normophosphatemic Type), Inclusion Body Myophy Type 28, Metachromic Leukodystrophy, Polyglandular Deficiency Syndrome, Pseudocholinesterase Deficiency, Spinal Muscular Athrophy (S.MA) and Wolman Disease.
21 (1): 8-17, the Alpha-thalassemia
gene is highly prevalent in Saudi Arabia and the interaction with the sickle cell gene is commonly observed.
High prevalence of alpha-thalassemia
among individuals with microcytosis and hypochromia without anemia.
The study results "make a strong case for newborn screening for alpha-thalassemia
, at least in states with a substantial increase in their Asian populations.
Prenatal ultrasonographic prediction of homozygous type 1 alpha-thalassemia
at 12 to 13 weeks of gestation.
Two of these were found to have co-existing alpha-thalassemia
. Of the remainder, 11 (55%) were determined to have a low-normal hematocrit (mean=31.5 [+ or -] 0.9), 1 had alpha thalassemia alone, 1 had coexisting alpha-thalassemia
and hemoglobin AS, and 1 had hemoglobin SC.