has two jobs in parts of the hypothalamus region of the brain.
Previous studies show that the substance, called alpha melanocyte stimulating hormone, or alpha-MSH
, has anti-inflammatory properties.
Melatonin, prolactin and alpha-MSH
, hormones known to control sharks' skin coloration, are key in regulating glow.
It is now established that leptin action in the hypothalamus in regulation of food intake and body weight is mediated by a neural circuitry comprising of orexigenic and anorectic signals, including NPY, MCH, galanin, orexin, GALP, alpha-MSH
, NT, and CRH.
The patented technologies invented by a team of researchers at CTT's client, the University of Arizona, are synthetic analogues of alpha-MSH
(alpha-melanocyte-stimulating hormone), a natural hormone secreted by the pituitary gland and skin cells.
Bremelanotide, which is a melanocortin agonist (a compound which binds to a cell receptor and triggers a response) drug candidate, is a synthetic peptide analog of the naturally occurring hormone alpha-MSH
The scientists showed in laboratory tests alpha-MSH
combined with a widely-used polymer produced a material that fights inflammation in dental pulp fibroblasts.
Researchers found that blocking the PRCP enzyme keeps the alpha-MSH
peptides from being degraded, resulting in higher levels of alpha-MSH
and decreased appetite.