Alpha-MSH induces dendritic release of oxytocin in the PVN through the MC4R (48).
Plasma concentrations of
alpha-MSH, AgRP and leptin in lean and obese men and their relationship to differing states of energy balance perturbation.
It is a synthetic analog of the hormone alpha-melanocyte--stimulating hormone (
alpha-MSH).
Nillni, professor of medicine at Brown University and a researcher at Rhode Island Hospital, observed that after meals obese rats had a dearth of another key hormone --
alpha-MSH -- compared to rats of normal weight.
Melitane is a biomimetic peptide derived from
alpha-MSH. Melitane stimulates melanin synthesis and decreases the number of white and low-pigmented hair and increases the number of moderate and highly pigmented cells on hair bulb
Previous studies show that the substance, called alpha melanocyte stimulating hormone, or
alpha-MSH, has anti-inflammatory properties.
Melatonin, prolactin and
alpha-MSH, hormones known to control sharks' skin coloration, are key in regulating glow.
It is now established that leptin action in the hypothalamus in regulation of food intake and body weight is mediated by a neural circuitry comprising of orexigenic and anorectic signals, including NPY, MCH, galanin, orexin, GALP,
alpha-MSH, NT, and CRH.
Bremelanotide, which is a melanocortin agonist (a compound which binds to a cell receptor and triggers a response) drug candidate, is a synthetic peptide analog of the naturally occurring hormone
alpha-MSH (melanocyte-stimulating hormone).