have the opposite function of beta cells.
The molecule activates adult pancreatic beta and alpha cell
All the groups showed central concentration of beta cells with an occasional presence of alpha cells
in between beta cells.
Failure of suppression of glucagon secretion from the alpha cells
of the pancreas contributes to hyperglycaemia in T2DM and is aLso seen in prediabetes.
If the discovery translates to people, scientists may one day be able to coax type 1 diabetics' own alpha cells
into replacing insulin-producing cells.
That's because it will likely require development of a glucagon-releasing system functioning akin to the pancreatic alpha cell
, in addition to insulin release in response to CGM data.
This supports our hypothesis that the antihyperglycaemic effect of stevioside is primarily due to a direct action on the insulin producing beta cells and glucagon producing alpha cells
In those mice, but not in normal mice, they found that caerulein caused existing alpha cells
in the pancreas to differentiate into insulin-producing beta cells.
Conversely, alpha cells
secrete glucagon, a hormone that triggers tissues to release sugar into the bloodstream.
In the past three months, the Powers group at Vanderbilt, in four separate papers, has reported important findings about the "microenvironment" of the insulin-secreting beta cells and glucagon-secreting alpha cells
, which are among four types of cells clustered in "islets" in the pancreas.
Our study shows that neighboring cells called alpha cells
can behave like adversaries for beta cells.
While the alpha cells
of the pancreas that produce glucagon are not destroyed in people with type 1 diabetes, the cells no longer release glucagon in response to low blood sugar.