Omalizumab, anti-IgE recombinant humanized monoclonal antibody, for the treatment of severe allergic asthma
. J Allergy Clin Immunol.
Methods: Patients with allergic asthma
were included in a randomized controlled trial and randomized to receive up to 15 acupuncture sessions over 3 months or to a control group receiving routine care alone.
Conclusion: Prevalence of allergic asthma
was high and the most common allergen causing highest sensitisation was house dust mite.
Professor Graham Roberts, a consultant in paediatric allergy and respiratory medicine, said: "We know exposing children with allergic asthma
to a small dose of whatever they are allergic to can reduce their body's reaction to the trigger and this, in turn, reduces the likelihood of asthma attacks and further problems in the future.
The aim of this study was dual: to assess the impact of biomarkers on the obstructive disorders of ventilation and pathophysiology of allergic asthma
; and to determine the frequency of 4G/5G polymorphism in the promoter region of the PAI-1 gene in patients with asthma and compare it with control group consisting of people with no asthma and allergy symptoms.
In addition, we found that the activation of NLRP3 helped promote allergic asthma
and that this process was independent of inflammasome activation.
Cellular inflammation of the airways with eosinophils is a characteristic feature of allergic asthma
(Zissler et al.
is a disease which mostly exists at the Mediterranean coast (1).
The cells produce proteins that can cause lung inflammation due to allergic asthma
triggers, such as dust mites or pet hair.
was diagnosed by the following criteria: Positive skin prick test result (to rye pollen, birch pollen, grass pollen, cat, or Dermatophagoides pteronissinus/farinae) and specific IgE.
The pathophysiologic mechanism of allergic asthma
and rhinosinusitis is so complicated and involves thousands of inflammatory mediators.
Immunotherapy, often referred to as desensitization, is the closest thing to a cure for allergic diseases and is an established treatment for severe allergies such as allergic rhinitis and allergic asthma
. Its administration includes increasing the doses of allergen extracts over a span of time either through injections or sublingual tablets and drops.
"We found that by adding a signalling molecule, Interleukin 1 (IL-1) using an experimental model of allergic asthma
, the symptoms would worsen dramatically," explained Dr Caucheteux.
[USPRwire, Wed Mar 25 2015] Global Markets Direct's, 'Allergic Asthma
- Pipeline Review, H1 2015', provides an overview of the Allergic Asthma
's therapeutic pipeline.
TEHRAN (FNA)- Giving a mild allergic asthma
patient an antibody, which blocks a specific protein in the lungs, markedly improved asthmatic symptoms such as wheezing, breathlessness, chest tightness and cough after the allergic asthmatics had inhaled an environmental allergen, a study revealed.