: Aldosterone antagonists
may reduce free testosterone levels and compete with androgens binding at the sebaceous gland.
Angiotensin Converting Enzyme Inhibitors (ACEI), Angiotensin Receptor Blockers (ARB), Aldosterone antagonists
In short, diuretics (and aldosterone antagonists
) provide optimal relief of edema.
-- The latest heart failure guidelines from the American College of Cardiology/ American Heart Association place a new emphasis on aldosterone antagonists
as a central aspect of the management of symptomatic or previously symptomatic heart failure with reduced ejection fraction--while underscoring important caveats to their use.
(8) Aldosterone antagonists
are also indicated for patients with reduced EF who have, or recently had, rest dyspnea.
Their use in combination with an aldosterone antagonist
such as spironolactone can decrease their hypofibrinolytic effects and metabolic side effects.
Assmann et al., "Regional variation in patients and outcomes in the treatment of preserved cardiac function heart failure with an aldosterone antagonist
(TOPCAT) trial," Circulation, vol.
DALLAS -- Spironolactone did not hit a home run in the large international "treatment of preserved cardiac function heart failure with an aldosterone antagonist
" (TOPCAT) trial, but it did knock out a solid single in the form of significantly reduced hospitalizations for this extremely common, chronic, high morbidity/mortality condition.
All patients were started on an aldosterone antagonist
(spironolactone) on the same day as receiving their first dose of RLY5016.
Furthermore, reliable quantification of aldosterone is critical during subsequent suppression testing (in which the definitive confirmation or exclusion of primary aldosteronism depends on the measured aldosterone concentration) and adrenal venous sampling, the results of which largely determine whether a patient is a candidate for unilateral adrenalectomy, or alternatively, treatment with aldosterone antagonist
And aldosterone blockade with an aldosterone antagonist
has been shown to improve clinical outcomes in heart failure patients with a depressed left ventricular ejection fraction in RALES, the Randomized Aldactone Evaluation Study (N.
Spironolactone HCl is a synthetic 17-lactone drug that is a renal competitive aldosterone antagonist
in the class of pharmaceuticals known as potassium-sparing diuretics.
In 2004, the Candesartan in Heart failure Assessment of Reduction in Mortality and morbidity trial (CHARM) (30) found that when the ARB candesartan (Atacand) was added to standard therapy (ACE inhibitor, beta-blockers, aldosterone antagonist
) there was a 33% reduction in all-cause mortality, similar to that found with beta-blockers and ACE inhibitors) (LOE: 1).