Diabetic complications including neuropathy, nephropathy, cataracts, and retinopathy are considered to result from the accumulation of sorbitol, which is obtained from reduction of glucose by the catalytic activity of aldose reductase (AR, EC 18.104.22.168) in the polyol pathway.
hexaphylla leaves' (SHL) constituents on rat lens aldose reductase (RLAR) and AGEs.
Lim, "Aldose reductase inhibitory activity of compounds from Zea mays L.," BioMed Research International, vol.
Begum, "Kinetics and mechanism of the oxidation of some aldoses
, amino sugars and methylated sugars by tris(pyridine-2-carboxylato)manganese(III) in weakly acidic medium," Carbohydrate Research, vol.
Acid-catalyzed reductive amination of aldoses
In contrast, the activity of aldose reductase remained at about 8 [micro]mol/min [multiplied by] mg protein throughout germination [ILLUSTRATION FOR FIGURE 4 OMITTED].
Sorbitol breakdown may result from an increase in the activity of sorbitol dehydrogenase (the catabolic enzyme), a decrease in the activity of aldose reductase (the anabolic enzyme), or both.
Aldose reductase from seminal vesicle and placenta of ruminants.