Gallamine (134) and alcuronium
(135) are original ligands with such properties: gallamine suppresses the [[sup.3]H]NMS binding of cardiac muscarinic receptors ([M.sub.2] receptors) without competing with [[sup.3]H]NMS, whereas alcuronium
enhances the [[sup.3]H]NMS binding.
(A side-effect of this was tachypnoea due to decreased compliance of the chest wall.) Another study showed that children with malignant tumours of kidney, liver or bone required larger doses of d-tubocurarine or alcuronium
, in contrast to those with benign tumours or those whose malignant tumours had been treated successfully by radiation, chemotherapy or surgery, who responded normally.
Puhringer F, Adler R, Mitterschiffthaler G, Koller J, Mair P, Khunl-Brady KS, Agoston S (1990) The dose-response relationship and time course of the neuromuscular blockade by alcuronium
. Anaesthesist 39: 508-512
Anesthesia was induced with thiopentone and alcuronium
was the muscle relaxant of choice.
In 1 study in kestrels (Falco tinnunculus), the mydriatic effect of topical administration of 3 different NMBAs (alcuronium
chloride, pancuronium bromide, and vecuronium bromide) was evaluated.