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  • noun

Synonyms for agonist

the principal character in a work of fiction


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someone involved in a contest or battle (as in an agon)

a muscle that contracts while another relaxes

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(biochemistry) a drug that can combine with a receptor on a cell to produce a physiological reaction

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Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc.
References in periodicals archive ?
For RefChemDB, records were extracted from LitDB that contained annotations for chemicals and activity on targets (antagonism or agonism).
While the first one was more of a bookish culture, I was inclined towards the curious term of agonism - unique in meaning, and unrecognisable in origin.
The fast dissociation with the D2 receptors, 5-HT2a antagonism and 5-HT1a agonism are the unique features which make these drugs better than the conventional, standard antipsychotics (Lind et al., 2005).
Intrathecal [alpha]2 receptor agonism in the dorsal horn of the spinal cord can produce anti nociceptive action for both somatic and visceral pain.
First, serotonin may increase prolactin levels by stimulating postsynaptic 5-HT receptors located in the paraventricular nucleus of the hypothalamus via serotonin agonism. Second, it may indirectly increase prolactin by inhibiting dopamine, which is known to have an inhibiting function on prolactin in the tuberoinfundibular pathway (3).
When it works--such as in the inaugural installations of Southeast Asian and Singaporean art, and in the groundbreaking 2016 exhibition "Reframing Modernism"--viewers are able to tack back and forth between competing positions: The subtle agonism of looking heightens the interpretive stakes.
Any denial of antagonism through the model of agonism or consensus leads to what Mouffe would reiterate as the 'post-political model' (p52) which thwarts the cause of 'popular sovereignty' or political passion.
It may be difficult to see how this is an equivalent gift; indeed, male agonism, when it has not been friendly, has contributed to many social ills, such as sexism, crime, war, and domestic violence.
Agonism at the mu 1 and 2 receptors produces analgesia and respiratory depression, respectively, and agonism at the kappa receptor produces analgesia and sedation.
Stimulus trafficking, or biased agonism, which occurs when high concentrations of epinephrine initiate a switch from G(s) protein to G(i) protein signaling in ventricular cardiomyocytes via the beta(2)-adrenoceptor could also explain the pathophysiology of Takotsubo syndrome.
In addition, the similar effects of 5-HT2A receptor agonist and antagonist on food intake [14-16] might be due to the paradoxical phenomenon that both agonism and antagonism of 5-HT2A receptors induce 5-HT2A receptor's desensitization or downregulation [17].
Quetiapine is an atypical antipsychotic that possesses low to moderate antagonist activity at multiple neurotransmitter receptors, including serotonergic 5-hydroxytryptamine (5-[HT.sub.2A]) receptors, dopaminergic ([D.sub.1] and [D.sub.2]) receptors, histaminergic ([H.sub.1]) receptors, and adrenergic [[alpha].sub.1] and [[alpha].sub.2] receptors, and partial agonism at 5-[HT.sub.1A] receptors [1].
Furthermore, TLR3 agonism upregulated type I interferon (IFN[beta]) and IFN-responsive genes and inflammatory mediators in SMG tissue, including IL-6, IL-1fi, and CCL5 [39, 40].
In general, agonism of presynaptic alpha-2 receptors causes decreased release of norepinephrine.