For RefChemDB, records were extracted from LitDB that contained annotations for chemicals and activity on targets (antagonism or agonism
While the first one was more of a bookish culture, I was inclined towards the curious term of agonism
- unique in meaning, and unrecognisable in origin.
The fast dissociation with the D2 receptors, 5-HT2a antagonism and 5-HT1a agonism
are the unique features which make these drugs better than the conventional, standard antipsychotics (Lind et al., 2005).
Intrathecal [alpha]2 receptor agonism
in the dorsal horn of the spinal cord can produce anti nociceptive action for both somatic and visceral pain.
First, serotonin may increase prolactin levels by stimulating postsynaptic 5-HT receptors located in the paraventricular nucleus of the hypothalamus via serotonin agonism
. Second, it may indirectly increase prolactin by inhibiting dopamine, which is known to have an inhibiting function on prolactin in the tuberoinfundibular pathway (3).
When it works--such as in the inaugural installations of Southeast Asian and Singaporean art, and in the groundbreaking 2016 exhibition "Reframing Modernism"--viewers are able to tack back and forth between competing positions: The subtle agonism
of looking heightens the interpretive stakes.
Any denial of antagonism through the model of agonism
or consensus leads to what Mouffe would reiterate as the 'post-political model' (p52) which thwarts the cause of 'popular sovereignty' or political passion.
It may be difficult to see how this is an equivalent gift; indeed, male agonism
, when it has not been friendly, has contributed to many social ills, such as sexism, crime, war, and domestic violence.
at the mu 1 and 2 receptors produces analgesia and respiratory depression, respectively, and agonism
at the kappa receptor produces analgesia and sedation.
Stimulus trafficking, or biased agonism
, which occurs when high concentrations of epinephrine initiate a switch from G(s) protein to G(i) protein signaling in ventricular cardiomyocytes via the beta(2)-adrenoceptor could also explain the pathophysiology of Takotsubo syndrome.
In addition, the similar effects of 5-HT2A receptor agonist and antagonist on food intake [14-16] might be due to the paradoxical phenomenon that both agonism
and antagonism of 5-HT2A receptors induce 5-HT2A receptor's desensitization or downregulation .
Quetiapine is an atypical antipsychotic that possesses low to moderate antagonist activity at multiple neurotransmitter receptors, including serotonergic 5-hydroxytryptamine (5-[HT.sub.2A]) receptors, dopaminergic ([D.sub.1] and [D.sub.2]) receptors, histaminergic ([H.sub.1]) receptors, and adrenergic [[alpha].sub.1] and [[alpha].sub.2] receptors, and partial agonism
at 5-[HT.sub.1A] receptors .
Furthermore, TLR3 agonism
upregulated type I interferon (IFN[beta]) and IFN-responsive genes and inflammatory mediators in SMG tissue, including IL-6, IL-1fi, and CCL5 [39, 40].
In general, agonism
of presynaptic alpha-2 receptors causes decreased release of norepinephrine.