For NiV, the standard is the
African green monkey model.
Ultrastructure of the Leydig cells in the
African green monkey. J.
African green monkey kidney Vero cells require de novo protein synthesis for efficient herpes simplex virus 1-dependent apoptosis.
Solange Gennari, USP) foram inoculados em oito cultivos celulares: cultivo primario de rim, pulmao e testiculo bovino; celulas MDBK (Madin Darby bovine kidney), MDCK (Madin Darby canine kidney), RK-13 (rabbit kidney), MA-104 (
African Green Monkey kidney cells) e VERO (
African Green Monkey kidney cells).
The antisera were incubated with
African green monkey kidney Vero cells infected by SARS-CoV obtained from a SARS patient.
Most importantly,
African Green Monkey Kidney cells offer the researcher/investigator the luxury of having one cell line that can be used not only for isolation but also for the production of a potential viral vaccine, eliminating the need to adapt to another cell system.
In those primate species where high levels of SIV infection have been found in the wild, namely sooty mangabeys and
African green monkeys (the Cercopithecus aethiops super-species), it is primarily adults that are seropositive, leading to the hypothesis that SIV is normally transmitted through sexual activity.
Human polyomavirus related to
African green monkey lymphotropic polyomavirus.
Scientists still don't know the function of the "R" gene, but it may prove critical to an understanding of what makes SIV.sub.AGM nonpathogenic or what makes the
African green monkey resistant to the virus.
We studied the following 5 actual or candidate cell substrates used or proposed for production of biologic products: CHO-K1 (Chinese hamster ovary ATCC-CCL61); Vero C1008 (
African green monkey kidney ATCC-CRL1586); WI-38 (human lung diploid fibroblasts ATCC-CCL75); MDCK (dog kidney ATCC-CCL34); and HEK-293 (human embryonic kidney ATCC-CRL-1573 transformed with defective adenovirus as a surrogate for PER.C6) (Crucell, Leiden, Netherlands) (Table 1).
"We predict that there will be other viruses in the spectrum that range from the
African green monkey prototype ...
The matrixes were based on monkey B-lymphotropic papovavirus M30540 and
African green monkey polyomavirus NC_004763 sequence annotations for VP1 and LT genes, respectively.
Genetic stability of foamy viruses: long-term study in an
African green monkey population.
At INEVH, virus was isolated in
African green monkey (Vero) cells, as described (2).
COS cells are a derivative of the
African green monkey kidney fibroblast cell line CV-1, which is highly susceptible to SARS-CoV.
