Their topics include the humanization of antibodies, affinity maturation
approaches for antibody lead optimization, antibody expression from bacteria to transgenic animals, the design and application of immunoconjugates for cancer therapy, and dual-targeting bispecific antibodies as new therapeutic modalities for cancer.
GenScript offers extensive antibody drug services that include antigen production, hybridoma development and stabilization, antibody sequencing, chimeric antibody, antibody humanization, affinity maturation
, epitope mapping, antibody and protein characterization, in vitro assay and screening, in vivo efficacy and safety study, antibody transient expression, stable cell line, and scale up production.
The clonal selection algorithm (CSA) is a special kind of immune algorithms using the clonal expansion and the affinity maturation
as the main forces of the evolutionary process.
The ProteOn is also used downstream to monitor the preservation of Fab affinity after the affinity maturation
1A) has proven to be a highly effective platform for various directed evolution applications, including affinity maturation
(10-12) and changes in specificity (13, 14).
refers to the process whereby better antibodies persist that have a higher affinity for the vaccine antigen as time goes by after vaccination because as antigen becomes more scarce, the higher affinity antibodies outcompete the lower affinity antibodies--and that is good.
The Xenerex system is able to take advantage of the unique in vivo cellular interactions, which occur in the human immune system that result in natural affinity maturation