A fixed combination of lovastatin with extended-release niacin (Advicor
) is commercially available.
The data came from ADVOCATE (Advicor
Versus Other Cholesterol-Modulating Agents Trial Evaluation), which compared overall lipid changes in 315 dyslipidemic patients randomized to either Kos Pharmaceutical's fixed-dose single-tablet combination, atorvastatin, or simvastatin for 16 weeks (Am.
The three-year agreement on the drugs, Niaspan and Advicor
, will take effect in January, enabling Takeda Pharmaceuticals North America Inc.
Also available combined with extended-release niacin (Advicor
Statins are also found in the combination medications Advicor
(lovastatin + niacin), Caduet (atorvastatin + amlodipine) and Vytorin (simvastatin + ezetimibe).
Kos' two most prominent drugs in the segment are Niaspan, an extended-release tablet that raises HDL (good cholesterol), and Advicor
, another extended-release tablet that treats multiple lipid disorders.
If a person does not respond adequately to any single drug therapy, a combination drug should be considered, such as lovastatin plus niacin (Advicor
) received Food and Drug Administration approval in December.