(18) Miyahara H, Itou H, Sekine A, Taniyama D, Katsui T, Tanaka W A case of adult T-cell leukemia/lymphoma
with primary lung cancer.
miRagen Therapeutics announced the first observations on the safety and efficacy of cobomarsen in adult T-cell leukemia/lymphoma
, or ATLL, patients, a highly morbid T-cell malignancy seen in patients previously infected with the human T-lymphotropic virus type 1, or HTLV1.
Hane et al., "Development of a sensitive two-site immunoradiometric assay for parathyroid hormone-related peptide: evidence for elevated levels in plasma from patients with adult T-cell leukemia/lymphoma
and B-cell lymphoma," Journal of Clinical Endocrinology and Metabolism, vol.
(1,2) Despite that 95% of the HTLV-1 infected individuals remain asymptomatic, this infection can cause syndromes such as adult T-cell leukemia/lymphoma
(ATLL), HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), polymyositis, arthritis and infective dermatitis.
Augmented expression of programmed death-1 in both neoplastic and non-neoplastic [CD4.sup.+] T-cells in adult T-cell leukemia/lymphoma
. Int J Cancer.
Adult T-cell leukemia/lymphoma
(ATLL) is an uncommon lymphoproliferative disorder of mature [CD4.sup.+] T cells that is caused by the retrovirus human T-lymphotrophic virus type 1 (HTLV-1).
Profiling of ALK+ ALCL and ALK- ALCL by The International T-Cell Lymphoma Project, and comparison with AITL, adult T-cell leukemia/lymphoma
, and PTCL-NOS, revealed that ALK+ ALCL could be separated from these entities at the molecular level.
Adult T-Cell Leukemia/Lymphoma
(HTLV1+): panT+ ([CD2.sup.+], [CD3.sup.+], [CD5.sup.+]), [CD7.sup.-], [CD4.sup.+], [CD8.sup.-], [CD10.sup.+], [CD25.sup.+], TdT-; TCR gene rearrangements, clonally integrated HTLV1.