In a family study of a female adult T-cell leukemia
In contrast to HTLV-I, known to cause adult T-cell leukemia
, HTLV-II previously had been isolated in fewer than half a dozen people and cannot be definitively blamed for any ailment.
HTLV-I is a human type C retrovirus2 which has been etiologically associated with Adult T-Cell Leukemia
(ATL)and with a demyelinating neurologic disorder termed Tropical Spastic Paraparesis, and/or HTLV-I Associated Myelopathy (TSP/HAM).
Several cases of adult T-cell leukemia
have been described in patients of Romanian origin (9-14).
Food and Drug Administration for three indications: T-cell non-Hodgkin's lymphoma, including CTCL; chronic lymphocytic leukemia (CLL) and related leukemias including prolymphocytic leukemia, adult T-cell leukemia
, and hairy cell leukemia; and for treatment of acute lymphoblastic leukemia (ALL).
The HTLV-1 retrovirus is associated with adult T-cell leukemia
, a disease that is endemic in parts of Japan and the Caribbean.