Recent studies have identified the Wnt/GSK-3[beta]/[beta]-catenin-signaling pathway as a key regulator of adult neurogenesis in hippocampus [220, 221] or subventricular zone [222], highlighting the role of GSK-3[beta] on neural progenitor homeostasis [200].
The prevalence of adult neurogenesis in humans and primates is an area of active discussion in the field and more research is needed to determine whether the process of stem cell generation observed in the mouse pertains to other mammals too.
Adult neurogenesis occurring in the dentate gyrus of the hippocampus is a dynamic process regulated by both intrinsic and extrinsic factors (Aimone et al.
Effective management of degenerative diseases cannot be achieved by strategies that focus only on neuroprotection, whereas neuroregeneration through stem cell mediated adult neurogenesis needs to be promoted, in order to compensate for the functional deficits that occur due to neuronal loss.