These results indicate that GLe can promote adult neurogenesis
in the DG of the hippocampus and that increases of BDNF and TrkB expressions in the DG following GLe treatment might be closely associated with neurogenic effects of GLe.
produces a large pool of new granule cells in the dentate gyrus.
and funcional plasticity in neuronal circuits.
Research has shown that exercise can improve mood and cognition and has also demonstrated that a deficit in adult neurogenesis
may result in depressive disorders.
The most active areas of adult neurogenesis
are the subventricular zone (SVZ) of the lateral ventricles and the subgranular zone (SGZ) of the hippocampal dentate gyms.
In 2007, investigators at Yale University and other institutions formulated a hypothesis that exercise should alleviate the symptoms of MDD by way of adult neurogenesis
Alcohol, neural stem cells, and adult neurogenesis
Till, presented evidence for adult neurogenesis
in 1963, the older scientific "belief" was relegated to history, and was now pejoratively called "dogma"--something flimsy, merely based on blind, unsound, untrue, and scientifically unprovable assumptions.
Of late, however, evidence has been found showing that adult neurogenesis
takes place in two areas: the subventricular zone of the olfactory bulb and subgranular zone in the hippocampus's dentate gyrus.
Oxidative Stress in Adult Neurogenesis
and in the Pathogenesis of Alzheimer Disease
Hippocampal adult neurogenesis
is maintained by Neil3-dependent repair of oxidative DNA lesions in neural progenitor cells.
Revisiting adult neurogenesis
and the role of erythropoietin for neuronal and oligodendroglial differentiation in the hippocampus," Molecular Psychiatry, 2016.
We here propose to analyze the putative neuroprotective role of a specific immune-secreted Wnt subtype, Wnt3a, in stroke, as well as the effects of this ligand on adult neurogenesis
Their topics include cellular and functional aspects of adult neurogenesis
, skeletal muscle stem cells, visualizing neural stem cells to investigate neural development and the development of stem cell therapies, pluripotent stem cells from livestock, towards a European standard for human embryonic stem cell research, and stem cell technologies from generation to regeneration.
This process, called adult neurogenesis
, was first discovered by Goldman and Fernando Nottebohm of the Rockefeller University in the early 1980s, when die two realized that when learning new songs new neurons were added to regions of the bird's brain responsible for vocal control.