As for all other malignancies management and treatment of
adrenocortical carcinoma also requires a multidisciplinary team approach mainly including a medical oncologist, an endocrine surgeon and endocrinologist.
In our case, due to bleeding into the pseudocyst, MRI findings were suggestive of an
adrenocortical carcinoma. However, the presence of fat is not a common finding in
adrenocortical carcinomas (12).
Adrenocortical carcinoma: clinical and laboratory observations.
Extent of disease at presentation and outcome for
adrenocortical carcinoma: have we made progress?
The two most important predictive factors of
adrenocortical carcinoma are the size of the lesion and appearance on imaging [4].
Feminizing
adrenocortical carcinomas are defined as malignant tumors with estrogens overproduction with or without other adrenocortical hormones.
In the case of
adrenocortical carcinoma, a strict radiological followup in the post-operative period is required to detect the high rate of locoregional and metastatic recurrence.
Adrenocortical carcinoma (ACC) is a rare and highly aggressive malignant neoplasm with an incidence rate of 1 to 2 cases per million people per year.1,2 The overall 5-year survival is poor, ranging from 15-44% in reported series.3 Multimodality imaging with echocardiogram, computerized tomography (CT), positron emission tomography (PET) and magnetic resonance imaging (MRI) aids not only in establishing the diagnosis but also in anatomic evaluation to determine best surgical approach.
However, we have observed conventional
adrenocortical carcinomas with a wide range of TSPO expression, ranging from no expression to markedly increased TSPO expression [27].
Chapuis, "
Adrenocortical carcinoma extending into the inferior vena cava: presentation of a 15-patient series and review of the literature," Surgery, vol.
Global Markets Direct's, '
Adrenocortical Carcinoma (Adrenal Cortex Cancer) - Pipeline Review, H2 2015', provides an overview of the
Adrenocortical Carcinoma (Adrenal Cortex Cancer)'s therapeutic pipeline.
Ang II, insulin, and insulin-like growth factor 1 (IGF-1) were shown to play important roles in adrenocortical cells [11-13], and overexpression of IGF-1 receptor was found to be associated with the development of
adrenocortical carcinoma [14-17].
The presence of Li-Fraumeni syndrome increases the risk of osteosarcoma, breast cancer, colon cancer,
adrenocortical carcinoma, leukemia and lymphoma, and brain cancer.
In the
adrenocortical carcinoma samples, two of the eight tumors possessed the p.R337H mutation (Supplementary Table S2).
[USPRwire, Sun May 31 2015] Global Markets Direct's, '
Adrenocortical Carcinoma (Adrenal Cortex Cancer) - Pipeline Review, H1 2015', provides an overview of the
Adrenocortical Carcinoma (Adrenal Cortex Cancer)'s therapeutic pipeline.
