5,10] recognised that a decrease in attenuation of an adrenal mass between 140 kV and 80 kV is highly specific for an adrenal adenoma
2 cm) with features suggestive of an adrenal adenoma
This conclusion was made under the assumption that the benign lesion in question was an adrenal adenoma
, which is possible to distinguish radiographically given its fat component.
The definitive diagnosis was Cushing Disease in 10 subjects and ACTH-independent Cushing's syndrome due to an adrenal adenoma
in 10 subjects.
Despite the difference in the hypertension rate, actual blood pressure levels did not differ between the two groups because more of the adrenal adenoma
patients were taking antihypertensive medication than were the goiter patients, Dr.
Immunohistochemical negative control staining corresponding to adrenal adenoma
shown in Figure 1.
7) Rarely ectopic GHRH from thymic tumors, small cell lung cancer, adrenal adenoma
and pheochromocytoma have been reported.
Adrenal CT/MRI revealed adrenal hyperplasia in 5 (36%) and adrenal adenoma
in 9 (64%) patients with diagnosed Cushing's syndrome (CS) (See Table 4).
In two patients with adrenal adenoma
, therefore, the CT scan was inconclusive, while the diagnosis was made on MRI.
The first type of hyperfunctioning adrenal adenoma
is an aldosterone-producing tumor, or aldosteronoma (Figure 5), which accounts for up to 2% of all incidentally discovered adrenal masses.
2 FAI 8 Secondary adrenal insufficiency ADE 33 182 MER 36 124 Adrenal adenoma
TUR 1377 1258 ORT 1145 1068 Mean [+ or -] SD 973 [+ or -] 266 (n = 10) Range 568-1377 Cushing disease MON 411 4389 LAN 372 3925 Ectopic ACTH secretion BRE 9865 MOR 1574 IMO 786 Mean [+ or -] SD 2959 [+ or -] 3874 (n = 5) Range 786-9865 Cushing disease under OP'DDD MON 282 Ectopic ACTH under OP'DDD BRE 569 MOR 358 Chronic renal insufficiency Mean [+ or -] SD 387 [+ or -] 98 (n = 10) Range 265-568 11-HSD deficiency GON J-C 215 GON A 193 GON A (c) 146 Serum E, nmol/L [t.
The left adrenal gland pathology demonstrated a benign adrenal adenoma
An important characteristic of adrenal adenoma
is the presence of intracellular lipid.
of Tumors Adrenal cortical carcinoma 7/7 Adrenal adenoma
14/14 Metastatic carcinoma 0/16 Lung 0/8 Renal cell carcinoma 0/3 Breast 0/3 Hepatocellular 0/1 Esophagus 0/1 Pheochromocytoma 0/10 Table 2.
Two of the patients had primary adrenal insufficiency (Addison disease), two had secondary adrenal insufficiency (hypopituitarism),10 had adrenal adenoma
, two had Cushing disease, five had ectopic ACTH secretion, 10 were hypertensive patients with CRI, and two were cases of 11[beta]-OH steroid dehydrogenase deficiency (AME-1).