Separations of Cr, PCr, and adenine nucleotides
were performed on a 2.
There was no significant difference in the levels of adenine nucleotides
, PPi and Pi between non-bleeders and normal subjects but a significant decrease in the levels of adenine nucleotides
was observed in bleeders when compared with normal subjects.
6) They demonstrated that injection of a specific ecto-5'NT inhibitor, [alpha],[beta]-methylene ADP, suppressed the antiinflammatory properties of methotrexate in a murine air pouch model of inflammation, indicating that adenosine released from methotrexate treatment is derived from adenine nucleotides
converted extracellularly to adenosine.
Increase in plasma levels of adenosine and adenine nucleotides
after intravenous infusion of buflomedil in humans.
Effect of ribose supplementation on resynthesis of adenine nucleotides
after intense intermittent training in humans.
Decreased resting levels of adenine nucleotides
in human skeletal muscle after high-intensity training.
This phenomenon could be linked to the finding that significant depletion of ATP and adenine nucleotides
(which may indicate that they had been metabolized to urate) occurred only in rat liver slices incubated in a medium containing both glycerol and ethanol (9).
Heart and skeletal-muscle cells need adenine nucleotides
to produce adequate levels of adenosine triphosphate (ATP), the major energy producing molecule of all living cells.
5,227,371 entitled "Utilization of Adenine Nucleotides
and/or Adenosine and Inorganic Phosphate for Elevation of Liver, Blood, and Blood Plasma ATP Concentrations" and U.
A hypothesis that could explain this metabolic insufficiency of the myocardium is that the biosynthesis of adenine nucleotides
is very slow in the normal heart and is increased only moderately during postischemic recovery  so that the replenishment of adenine nucleotides
is not affected appreciably.
In addition tissue, plasma, urine, and cerebrospinal fluid also contain adenine nucleotides
, and a specific method is necessary for reliable estimations.
The results of the Phase I study are to be presented at the 5th International Symposium on Adenosine and Adenine Nucleotides
, to be held in Philadelphia, May 9-13, 1994.
The effect of oral ribose supplementation on the resynthesis of adenine nucleotides
and performance after 1 wk of intense intermittent exercise was examined.