Objective: To analyze the acute phase reactants
in patients suffering from rheumatoid arthritis (RA) and compare them to healthy controls.
In addition, ceruloplasmin is an acute phase reactant
, so levels may be elevated in the setting of inflammation and tissue injury.
The presence of raised CRP in a major number of CKD children prove the survival of chronically activated acute phase reactant
C-reactive protein is basically an acute phase reactant
, which has been shown persistently elevated in cases of acute appendicitis.
SP-D is secreted as an acute phase reactant
, especially in the presence of infectious agents; it plays a role in host defense mechanisms via adhesion to micro-organisms due to its hydrophilic nature (6, 7), is important in aggregation, neutralization, and opsonization during phagocytosis, results in direct gram-negative bacterial cell-membrane lysis, inhibiting bacterial/fungal growth in macrophages, and has a aggregation-independent manner (7, 13).
It seems that increased body adipose tissue, particularly visceral depots, is associated with increased risk of iron deficiency which may be masked by high serum ferritin levels, presumably because the increase cytokines result in increased acute phase reactants
synthesis resulting in increased macrophage sequestration and/or decreased intestinal iron absorption.
Moreover our patient had high levels of acute phase reactants
at presentation which subsided under corticosteroid treatment.
Acute phase reactants
including CRP and ESR are used in differentiating between bacterial and viral infections since years.
the acute phase reactant
, C-reactive protein, which binds to the C-polysaccharide of many bacteria, promoting phagocytosis
The value of measurements of serum C-reactive protein (CRP), the classical acute phase reactant
, for monitoring patients of all ages is well established .
Acute phase reactant
(such as erythrocyte sedimentation rate)
1,2 IL-6 being an acute phase reactant
is also considered a proinflammatory cytokine, which is involved in the pathogenesis of coronary heart disease through autocrine, paracrine, and endocrine mechanisms.
CRP is an acute phase reactant
that starts rising within 6 hours of an insult (including acute pancreatitis) under influence of Interleukin-6 , peaks at around 48 hours and then declines with a half- life of 19 hours8.
FMF is a chronic inflammatory disease and level of C-reactive protein (CRP), the prototypic human acute phase reactant
increase during attacks.