reactant

Moreover our patient had high levels of acute phase reactants at presentation which subsided under corticosteroid treatment.

the acute phase reactant, C-reactive protein, which binds to the C-polysaccharide of many bacteria, promoting phagocytosis

For example, ferritin behaves as an acute phase reactant, which limits its diagnostic accuracy greatly.

Indicators of disease in RA could be a gene, a product of gene expression, cytokines, acute phase reactants, autoantibodies and tissue abnormalities, such as swollen and tender joints or degradation products of cartilage.

CRP is one of the acute phase reactants whose levels increase in response to inflammation.

Similar conclusions were reported in a follow-up report by the same group using serum amyloid A, another acute phase reactant, instead of hs-CRP (31).

The serum AA protein, most commonly seen in the course of FMF, is an acute phase reactant synthesized by the liver.

ACR 20, ACR 50 and ACR 70 responses indicate a 20, 50 and 70 percent improvement in the number of swollen and tender joints, respectively, as well as a 20, 50 and 70 percent improvement compared with baseline in three of five disease-activity measures: patient assessment, physician assessment, pain scale, Health Assessment Questionnaire and the value for one acute phase reactant (erythrocyte sedimentation rate or C-reactive protein).

Objectives: The aims of this study were to investigate a possible relationship between the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and some acute phase reactant (APR) levels in patients with ankylosing spondylitis (AS).

C-reactive protein (CRP) is the classic acute phase reactant.

Transcobalamin has been considered an acute phase reactant (1,2).

Assessment of iron status Parameter Comment * [down arrow] Hb Symptomatic iron deficiency may be persent first * [down arrow] MCV One of the last parameters to change * Ferritin [down arrow] Good measure of iron stores but also an acute phase reactant * Transferrin [up arrow] Helpful in interpreting ferritin level * [down arrow] serum iron Not reliable--affected by diet, * [down arrow] % saturation diurnal variation and hepcidin levels * [up arrow] sTfR Good measure of tissue iron deficiency but problems with assay * Bone marrow aspirate Not indicated Table II.

ACR 20 indicates a 20 percent improvement in the number of swollen and tender joints, as well as a 20 percent improvement compared with baseline in three of five disease-activity measures: patient assessment, physician assessment, pain scale, Health Assessment Questionnaire and the value for one acute phase reactant (erythrocyte sedimentation rate or C-reactive protein).

The acute phase reactant, C-reactive protein (CRP), is a most useful single marker that is cheap and easy to measure, but it also requires 48 h for maximal response (5, 6).

All four patients enrolled in the study to date experienced a positive response to a subcutaneous loading dose regimen of the IL-1 Trap, including a sizable reduction in daily patient diary scores and acute phase reactant levels.