Acute myeloid leukaemia
is a heterogenous group of disorders characterized by abnormal proliferation of clonal haemopoietic progenitor cells.1 Over the years, better understanding of the biology of disease has led to the identification of cytogenetic aberrations and molecular genetic alterations that not only have a role in leukemogenesis but also in disease progression.2 Specific genetic abnormalities define specific AML disease entities, thus being essential for diagnosis while others are known to have a role in determining prognosis, predicting response to treatment and overall survival.3 These genetic molecular markers may be therapeutic targets and can help guide treatment decisions.
Biopharmaceutical company Jazz Pharmaceuticals plc (Nasdaq:JAZZ ) Friday announced European Commission approval for Vyxeos 44 mg/100 mg powder for concentrate for solution for infusion for the treatment of adults with newly diagnosed, therapy-related acute myeloid leukaemia
(t-AML) or AML with myelodysplasia-related changes (AML-MRC), a rapidly progressing and life-threatening blood cancer.
Alvocidib is presently in Phase II development for the treatment of MCL-1-dependent acute myeloid leukaemia
Sadly, however, he died just three months after diagnosis with acute myeloid leukaemia
Methods: The retrospective cohort study was conducted at the National Institute of Blood Diseases and Bone Marrow Transplantation, Karachi, and comprised of medical record of acute myeloid leukaemia
patients from March 2006 to October 2016.
On August 17, 2015, four-andhalf-years after first claiming she was having cancer treatment, Tyreman finally revealed to the hospital trust that she did not have Acute Myeloid Leukaemia
Addition of gemtuzumab ozogamicin to induction chemotherapy in adult patients with acute myeloid leukaemia
: A meta-analysis of individual patient data from randomised controlled trials.
Melillo et al., "Spontaneous remission in acute myeloid leukaemia
: a role for endogenous production of tumour necrosis factor and interleukin-2?" British Journal of Haematology, vol.
Park, "Effective salvage therapy for high-risk relapsed or refractory acute myeloid leukaemia
with cisplatin in combination with high-dose cytarabine and etoposide," European Journal of Haematology, vol.
Das, "Mutations of NPM1 gene in de novo acute myeloid leukaemia
: determination of incidence, distribution pattern and identification of two novel mutations in Indian population," Hematological Oncology, vol.
Objective: To determine the clinical/haematological manifestations and frequency of different subtypes of Acute Myeloid Leukaemia
(AML) according to the French-American-British (FAB) classification.
Evaluation of seasonality in the diagnosis of acute myeloid leukaemia
among adults in the United States, 1992 2008.
London, April 16 ( ANI ): Researchers have found that gene mutations may play critically important role in acute myeloid leukaemia
- one of the most common types of human leukaemia- suggesting a promising new target for the condition.
It is the first time young people aged six months to 18 with acute lymphoblastic leukaemia and acute myeloid leukaemia
have received a pioneering class of drugs called aurora kinase inhibitors.
"The Cardiff ECMC is leading the world's largest research trials in acute myeloid leukaemia
, a cancer of the blood cells which sees around 2,000 new cases in adults in the UK every year.