a painful inflammation of the big toe and foot caused by defects in uric acid metabolism resulting in deposits of the acid and its salts in the blood and joints
Acute gouty arthritis is initially triggered by the deposition of MSU crystals into the joints space and results in the maturation of several proinflammatory cytokines and neutrophil accumulation.
Acute gouty arthritis is an uncommon condition in women of reproductive potential, as only about 10%-15% of cases involve women and it typically occurs after menopause (J.
The clinical manifestations of gout (acute gouty arthritis, gouty arthropathy, chronic tophaceous gout, uric acid urolithiasis, and gouty nephropathy) result from deposition of monosodium urate or uric acid crystals from supersaturated body fluids.
Although monosodium urate (MSU) crystals in synovial fluid were not observed under polarizing microscope, the typical clinical and laboratory findings supported a diagnosis of acute gouty arthritis according to preliminary criteria for diagnosis of acute gout (10).
Mk is a selective antagonist of the LTD4 receptor, a pathway shown to play minor role gouty arthritis (26, 27), Therefore, it is possible that LTD4 may have a heretofore unknown role in acute gouty arthritis. Alternatively, Mk may act inhibiting the synthesis and/or the effect of LTB4 as recently suggested by the demonstration that antagonist of LT receptors are alosteric inhibitors of the 5-lipooxygenase enzyme (28).
Song, "Randomized and controlled clinical study of modified prescriptions of Simiao Pill in the treatment of acute gouty arthritis," Chinese Journal of Integrative Medicine, vol.
Three clinical syndromes are associated with gouty arthritis: acute gouty arthritis, intercritical gout (or interval gout), and chronic recurrent and tophaceous gout.