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Examples are Actrapid (Novo Nordisk, Baulkham Hills, NSW) and Humulin R (Eli Lilly, West Ryde, NSW).
Blood samples for cortisol were obtained at -20, 0, 30, 60, 90 and 120 min after administration of regular insulin (human Actrapid, Novo-Nordisk, Denmark) at a dose of 0.1-0.2 U/kg IV bolus.
Basal blood samples were drawn at 30,10, and 5 min before the glucose injection, after which glucose (300 mg/kg of body weight) was injected over 1 min starting at time 0, and insulin (0.03 N/kg; Actrapid; Novo) was administered at time 20 min.
Following a 2-hour fast, insulin tolerance was assessed by the intraperitoneal administration of regular human insulin (0.75 U/kg Actrapid; Novo Nordisk) and monitoring blood glucose.
Initially rapid short acting regular insulin (human actrapid) was given subcutaneously.
That only two oral medications (metformin and glibenclamide) and three insulin formulations (Actrapid, Actraphane and Protophanc) are available on the national formulary also illustrates how T2DM remains under-prioritised at a policy level.
This test was performed by intraperitoneal injection of insulin bolus (4IU/kg; Actrapid, Novo-Nordisk).
All the patients were treated with intensified insulin therapy, multiple daily (subcutaneous) injection, 4 daily doses, human rapid acting insulin (Actrapid HM 100, Novo Nordisk) before the meals and in the evening at bedtime, and NPH insulin (Insulatard HM 100, Novo Nordisk).
The hyperinsulinemic-euglycemic clamp was performed (0-120 min) by a continuous infusion of human insulin (3 mU/kg/min) (Actrapid, Novo Nordisk, Bagsvaerd, Denmark), and euglycemia (~ 115 mg/dL) was maintained by variable infusion rates of a 20% nonlabeled glucose solution [glucose infusion rate (GIR)].
A basal sample was collected and short acting human insulin 0.1 IU/kg body weight (Human Actrapid, NovoNordisk India Private Ltd., Bangalore, India) was given as an intravenous bolus at 0900 h.
Rapid reversion to sinus rhythm followed administration of 1.4 mmol of calcium chloride and two units of insulin (Actrapid, Novo Nordisk).
Insulin (Actrapid; [10.sup.5] N/L) was purchased from Novo Nordisk A/S.