Irene Weber continued her structural investigation of the Escherichia coli catabolite gene activator protein
Because the remaining LSDs not identified by LAMP-1 were predominantly those that stored sphingolipids, we have studied the sphingolipid activator proteins
, or saposins, as potential complementary markers.
Expression of FRA-1 was also studied, because FRA-1 belongs to the activator protein
1 family of transcription factors and members of this family are known to interact with NF-[kappa]B.
Recent SANS experiments have confirmed that the gene activator protein
, cyclic AMP receptor protein (CRP), undergoes a significant structural, or conformational, change in solution upon DNA binding.
1 (AP-1)- and nuclear factor kappaB (NF-kappaB)-dependent transcriptional events in carcinogenesis.
Effective therapy depends on producing sufficient quantities of the protein, which, in turn, is limited by the potency of the gene activator protein
The patent claims cover the preparation of a tissue plasminogen activator protein
by expression in a recombinant host organism and includes recombinant human t-PA, alleles and derivatives by way of deletion, substitution, insertion, addition, or replacement of its amino acids.
ARIAD scientists have shown that maximal protein production in the cell is highly dependent on the composition and structure of gene activator proteins
(also known as transcription factors) used to turn on gene expression and that this process can be enhanced dramatically by clustering the gene activator proteins
together in unique ways or by modifying them at specific sequence sites - the basis of ARIAD's new technology.
6,015,709, issued on January 18, 2000, covers a proprietary class of highly potent gene activator proteins
used in the ARIAD Gene Activation Technology.