Helioid inclusions in dedifferentiated acinic cell carcinoma
of the parotid gland.
Acinic cell carcinoma
of palate a rare presentation.
19,20) Acinic cell carcinoma
is more frequently located in the parotid and sublingual glands, most often in patients near 10 years of age.
7) Other diagnostic challenges may include clear cell neoplasms such as metastatic renal cell carcinomas, which can mimic a primary lymphoid-rich acinic cell carcinoma
National Cancer Data Base report on cancer of the head and neck: Acinic cell carcinoma
of False Neoplastic Site ([dagger]) dagger]) Diagnoses by Pathologists Liver 180 37 Hepatocellular adenoma, 36 Hepatocellular carcinoma, 21 Benign neoplasm NOS, 5 Metastatic carcinoma NOS, 1 Metastatic small cell carcinoma, 1 Adenocarcinoma (primary or metastatic), 2 Pancreas 171 10 Islet cell or neuroendocrine tumor, 12 Microcystic adenoma, 1 Lympoma, 1 Adenocarcinoma, 1 Carcinoma NOS, 1 Benign neoplasm NOS, 1 Salivary 272 6 Acinic cell carcinoma
, 4 gland Squamous cell carcinoma, 2 Monomorphic adenoma, 3 Adenoid cystic carcinoma, 1 Warthin tumor, 1 Benign neoplasm NOS, 5 Kidney 102 60 Renal cell carcinoma, 59 Angiomyolipoma, 1 Metastatic carcinoma NOS, 1 * FNA indicates fine-needle aspiration; NOS, not otherwise specified.
No zymogen granules were identified, ruling out acinic cell carcinoma
2-4) With regard to the prevalence of parotid gland cancers in children, acinic cell carcinoma
is second only to mucoepidermoid carcinoma.
According to sources cited by Kim and Mathog, mortality from acinic cell carcinoma
at 20 years is as high as:
Histologically, acinic cell carcinoma
may exhibit any and all of the following growth patterns: solid, microcystic with thyroidlike appearance, papillary-cystic, and follicular The most common patterns are solid and microcystic.
In the sixth patient, cytology of a parotid mass was consistent with an adenoma, but excisional biopsy later revealed that it was an acinic cell carcinoma
2) The incidence of salivary tumors in children is not clearly defined; at our institution, a previous 14-year retrospective study found 92% of the salivary gland tumors excised were pleomorphic adenomas, with the other tumors being acinic cell carcinomas
Moran, MD, of the University of Texas MD Anderson Cancer Center, featuring pathology slides of adenocarcinomas, acinic cell carcinomas
, and other neoplasms of the pancreas.
Most of these tumors have likely been diagnosed as acinic cell carcinomas
in the past because of some histologic overlap between these 2 tumors.
The cases chosen included 12 Warthin tumors (cystadenoma lymphomatosum papilliferum), 16 benign mixed tumors (pleomorphic adenomas), 5 adenoid cystic carcinomas, 6 acinic cell carcinomas
, 8 polymorphous low-grade carcinomas, and 2 mucoepidermoid carcinomas.