A variety of buffer systems contribute toward the maintenance of acid-base homeostasis
, safeguarding against extreme acidosis and alkalosis conditions that could cause serious cellular dysfunction or even death.
DISCUSSION: The renal acid-base homeostasis
may be broadly divided into two processes: (1) reabsorption of filtered HCO3-, which occurs fundamentally in the proximal convoluted tubule; and (2) excretion of fixed acids through the titration of urinary buffers and the excretion of ammonium, which takes place primarily in the distal nephron.
Interpretation of ABG results requires an understanding of the underlying physiological mechanisms that maintain oxygen, carbon dioxide and acid-base homeostasis
. ABG levels relate to the integrated function of the respiratory, cardiovascular and renal systems.
They present the material in three main parts dealing with basic physiochemical concepts, fluid and electrolyte homeostasis, and acid-base homeostasis
, covering aspects related to both normal and abnormal physiology in each of the latter two sections.
CHAN, JCM., MAK, RHK., 2004, Acid-base homeostasis
. In Pediatric Nephrology.