Table 1 Type of Idiopathic Epilepsy Cases Percentage Idiopathic generalised tonic- 8 26.67% clonic seizures Idiopathic focal seizures 2 6.67% Absence epilepsy
3 10% Myoclonic astatic epilepsy 1 3.33% GEFS+ 1 3.33% JME 10 33.33% Idiopathic febrile seizures 5 16.67% n = 30 100% Table 2 Genotypes Cases Controls Total (%) [chi- P square] value C/C 18 24 42 (58.3%) 0.12 0.94 C/T 11 16 27 (37.5%) T/T 1 2 3 (4.2%) Total (%) 30 (41.7%) 42 (58.3%) 72 (100%) Table 3 Genotypes Cases Controls Total [chi- P value (%) square] GC/GC 9 15 24 (33.3%) GC/AT 15 21 36 (50.00%) 0.514 0.77 AT/AT 6 6 12 (16.67%) Total (%) 30 42 72 (41.6%) (58.3%) (100%)
The Neural Correlates of Childhood Absence Epilepsy
Japanese authors reported a patient with mutation in exon 7 of GLUD1 gene who presented with absence epilepsy
and eyelid myoclonia refractory to treatment and whose seizures intensified after protein-rich meals (15).
Long-term outcome of childhood absence epilepsy
: Dutch Study of Epilepsy in Childhood.
in rats is reduced by deprivation of REM sleep.
She was diagnosed with juvenile absence epilepsy
at the age of nine.
As in the case of absence epilepsy
, the enduring propensity of the system to generate seizures needs to be demonstrated.
Patients with juvenile myoclonic epilepsy tend to have similar or better quality of life scores in adulthood in comparison with patients with absence epilepsy
except when there are comorbid psychiatric conditions, according to findings from a case-control study.
Other generalized epilepsy syndromes include childhood absence epilepsy
, juvenile absence epilepsy
, and juvenile myoclonic epilepsy (JME)--all idiopathic with a probable genetic predisposition.
GABAB antagonists have antidepressant activity (Cryan and kaupman, 2005), cognition improvement (Froestl et al.,2004) and beneficial effects in rat models of absence epilepsy
(Manning et al., 2003).
found that the ApEn values of EEG signals in absence epilepsy
during seizure-free intervals are very similar to those of healthy subjects, but the EEG signals in absence epilepsy
during seizure intervals produce significant lower ApEn values than healthy subjects .
Li et al., "Altered resting-state connectivity during interictal generalized spike-wave discharges in drugnaive childhood absence epilepsy
," Human Brain Mapping, vol.
* Side effects- rare cognitive issues, may worsen myoclonic and absence epilepsy
, MRI changes in deep gray and white matter, usually transient and asymptomatic, weight gain, fatigue, somnolence, irritability, behavioral changes, psychosis, depression, ataxia; hyperactivity and agitation in children
Paroxysmal tonic upgaze of childhood with co-existent absence epilepsy
majority of absence epilepsy
: seizure control easily achieved with monotherapy; spontaneous remission usually occurs after a few years