The study supports the principle that genetic tests help physicians predict a drug's effect on patients, says Seth Hetherington of GlaxoSmithKline in Research Triangle Park, N.C., who has been conducting related experiments with abacavir
Hyderabad-based pharmaceutical firm Aurobindo Pharma (NSE: AUROPHARMA) announced on Thursday that it had been granted approval from the US Food and Drug Administration (FDA) to manufacture abacavir
sulfate and lamivudine tablets, which are used in the treatment of HIV.
In paediatric care, abacavir
is the current preferred first-line drug owing to concerns about tenofovir toxicity and also to to preserve AZT for a second-line NRTI backbone.
This trial (known as AACTG protocol A5095) compared abacavir
plus AZT plus 3TC vs.
* [Abstract 32] Patients with moderate or severe lipoatrophy who were taking either d4T (Zerit[R]) or AZT (Retrovir[R]) were randomly assigned to either continue their treatment, or substitute abacavir
(Ziagen[R]) for the d4T or AZT.
M2 PHARMA-February 24, 2012-Mylan Inc awarded tentative FDA approval for Abacavir
Sulfate and Lamivudine Tablets for pediatric HIV/AIDS(C)2012 M2 COMMUNICATIONS
Agenerase amprenavir Combivir [AZT+3TC] Crixivan indinavir Epivir lamivudine (3TC) Fortovase saquinavir Hivid zalcitabine (ddC) Kaletra lopinavir/ritonavir Norvir ritonavir Rescriptor delavirdine Retrovir zidovudine (AZT) Sustiva efavirienz Trizivir [abacavir+AZT+3TC] Videx didanosine (ddI) Viracept nelfinavir Viramune nevirapine Viread tenofovir DF Zerit stavudine (d4T) Ziagen abacavir
and lamivudine in combination with tenofovir should not be used as a triple antiretroviral therapy when considering a new treatment regimen for naive or pre-treated patients;
tablets are yellow, capsule-shaped, film-coated and imprinted with "GX623" on one side.
In DRIVE-FORWARD, PIFELTRO demonstrated sustained viral suppression through 48 weeks, meeting its primary endpoint of non-inferior efficacy compared to darunavir + ritonavir, each in combination with FTC/TDF or abacavir
sulfate and lamivudine tablets in 600 mg and 300 mg doses is a generic bioequivalent of VIV Healthcare's Epzicom tablets, used to treat HIV-1 infection, while olmesartan medoxomil and hydrochlorothiazide tablets, 20 mg/12.5 mg, 40 mg/12.5 mg and 40 mg/25 mg, have been judged therapeutically equivalent to Daiichi Sankyo Ltd.'s Benicar HCT, which is used to treat hypertension.