(27), although TG levels were quickly reduced by TPE, there was no statistically significant difference between the pre- and post-TPE APACHE scores
When controlling for severity of illness with the APACHE score
and for underlying disease with the Charlson index in a conditional logistic regression model, association with a longer hospital and ICU length of stay was approximately twice as likely for patients with MDR Acinetobacter infection as for susceptible references (Table 3).
This may also explain why the incidence of failed weaning dropped as the Apache score
increased (RR 0.96; 95% CI 0.92-0.98; P = 0.02), probably as these patients had respiratory compromise only with no other system compromise, hence the lower Apache score
The following variables were collected from the included studies by two independent reviewers: author, publication year, country, study design, main characteristics and severity of illness (APACHE scores
) of the study population, causative pathogens, antibiotic susceptibility testing methods and breakpoints, sites of infections, type and dose of polymyxin administered, coadministration of other antibiotics, outcomes (clinical response, microbiologic eradication, and mortality), and reported toxicity (nephrotoxicity and neurotoxicity).
The patients were stratified by neutropenic status and Apache score
, and there was no difference between the two drugs in outcome.
Patients with APACHE score
equal to or more than 15.
However, in a study performed on severe traumatic brain-injured patients with Glasgow Coma Scale scores between 5 and 8, APACHE score
was not significantly affected by probiotic treatment.35
Sample group is divided into the two subgroups (SG A = APACHE score
<5; SG B = APACHE score
Ranson's score requires 48 hours to complete the assessment and APACHE score
is cumbersome to use.
(%) 10 (47.6) Median dialysis days (SD, IQR) 0 (4.2, 0-3.5) Median APACHE score
(SD, IQR) 19.0 (6.4, 13.5-23.5) Median APACHE predicted mortality, 28.0 (18.0, 9.1-45.7) % (SD, IQR) Median ICU stay, days (SD, IQR) 8.0 (8.6, 3.0-13.5) Median hospital stay, days (SD, IQR) 35.0 (31.3, 15.5-55.5) Hospital mortality, no.