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Also, Concurrent autoimmune diseases such as Hashimoto's thyroiditis and rheumatoid arthritis were found in muscle-specific kinase (MuSK) antibody positive patients (9.6%) and Graves' disease was found in AChR-Ab positive patients.
Myasthenia gravis (MG) is an autoimmune neuromuscular disorder caused by anti-acetylcholine receptor antibodies (AChR-Abs) or other etiologies.
Neurological evaluation revealed negative acetylcholine receptor binding and blocking antibodies (AChR-Abs) and muscle-specific kinase antibodies (MuSK-Abs).
These results are also similar with the previous reports: 20–30% of NMOSD patients have been reported to present accompanying autoimmune disorders, and 40–50% of them have coexisting autoantibodies (organ and not organ specific).[sup][11] In particular, AchR-Abs (antibodies against acetylcholine receptor) might serve as a red flag in the differential diagnosis of NMOSD and MS.[sup][12] Although that NMOSD tends to be associated with autoimmune diseases is not fully understood, multiple evidence of the humoral mechanisms in NMOSD lesions were reported.[sup][13]
Seventeen patients had AChR-abs and 13 had anti-MuSK abs; in 4 MuSK-MG patients, a second sample was collected after rituximab (RTX) treatment.