In the present study, 20 hypertensive subjects with normal renal function who were being treated with an ACE inhibitor
or ARB were randomly assigned to consume a usual diet or a high-potassium diet, which was achieved by increasing intake of fruits and vegetables.
In normotensive patients with type 1 and type 2 diabetes, ACE inhibitor
therapy reduces the risk of developing diabetic kidney disease, defined as new-onset microalbuminuria or macroalbuminuria, by 18% (strength of recommendation [SOR]: C, meta-analysis of randomized controlled trials [RCTs], disease-oriented evidence).
The PARADIGM-HF Trial, the largest heart failure trial ever conducted, showed that patients with HF-rEF who were given sacubitril/valsartan were more likely to be alive and less likely to have been hospitalized for sudden deterioration of their heart failure than those given the ACE inhibitor
Patients with MI and heart failure should be put on long acting ACE Inhibitors
since cough is much less.
are typically well tolerated, but may cause a dry cough, and elevated potassium levels (hyperkalemia).
Angioedema is a potentially life-threatening adverse effect of ACE inhibitors
, with a reported incidence of 0.
In another study, McHenry and colleagues (2013) found no significant differences in fasting serum glucose or insulin concentration before and after therapies when a low-dose thiazide diuretic is combined with ACE inhibitors
I freely admit that I have been following yearly urinary microalbumin in my patients with diabetes who are already on an ACE inhibitor
or an angiotensin receptor blocker (ARB).
The researchers also assessed the impact of ACE inhibitors
on the brain power of 30 patients newly prescribed these drugs, during their first six months of treatment.
A retrospective analysis of longitudinal data from the prospective Health ABC (Dynamics of Health, Aging and Body Composition Study) found that femoral neck bone mineral density was significantly greater in elderly men on an ACE inhibitor
for 5 or more years for treatment of hypertension than in those not on long-term ACE inhibitor
The incidence of cough is similar among all ACE inhibitors
, the researchers wrote.
They stated that the results need further corroboration in other, larger clinical databases, although the surprising, apparently negative effect of ACE inhibitors
on the chances for recurrence is, at least, cause for concern.
A study of mice with high blood pressure found that ACE inhibitors
were only effective when taken just before sleep.
Because the two types of medicines do similar things, the insurance companies send me (and other MDs) notices that we should change our patients taking ARBs to ACE inhibitors
, because the latter are generic and cheaper.
If so, what are the guidelines on the discontinuation of ACE inhibitors
while receiving plasma therapy?