incompatibility

Deficiency of branched ABHI-active oligosaccharide chains on red cells of infants causes the weak antiglobulin reactions in hemolytic disease of the newborn due to ABO incompatibility. J Immunol 1980;124(6):2807-11.

Key words: ABO incompatibility, neonatal jaundice, blood group.

The principles of the management of major ABO incompatibility are given in Table 1.

Clinicians aggressively treat these symptoms in infants affected by ABO incompatibility, because hyperbilirubinemia can cause serious adverse effects for the baby if left untreated.

Anti-AB titer changes in patients with ABO incompatibility after living related transplantation.

Rh incompatibility is less of a problem than ABO incompatibility, says Klein.

Only a small fraction of DAT-positive infants develop clinical disease, and the incidence of severe hemolytic disease is very low.[2] Although the DAT is almost always positive in clinically significant hemolytic disease resulting from ABO incompatibility, the DAT may be negative.[1,2]

ABO incompatibility is a leading cause of neonatal jaundice and haemolytic disease of foetus and newborn (HDFN) in countries with high human development index.

The most common etiology or risk factor implicated was ABO incompatibility. These observations are similar to the results of other studies.

The most common cause of jaundice in the first 24 hours of life due to haemolytic disease of newborn (HDN) is rhesus (Rh) haemolytic disease2 followed by ABO incompatibility that may cause elevated levels of bilirubin and anaemia but less severe than Rh haemolytic disease.3

A study from Lahore reported hemolytic disease of newborn in 20.5%, ABO incompatibility in 58% and Rh incompatibility in 19% cases17.

*Duke immediately notified United Network for Organ Sharing about the ABO incompatibility and the need for new organs for Jesica.

Neonates having ABO incompatibility along with other minor blood group incompatibility.

Blood group has some association with diseases like duodenal ulcer, diabetes mellitus, urinary tract infection, Rh incompatibility and ABO incompatibility of newborn18.

Due to the immaturity of the babies' immune systems, the researchers said none experienced hyperacute rejection, and no morbidity was attributable to ABO incompatibility. Furthermore, despite the eventual development of antibodies to antigens of the donor's blood group in 2 of the infants, their grafts were not damaged.