Diyabetli yenidoganlar insulin tedavisine gereksinim duyarlar, ancak KCNJ11 ve ABCC8
genlerinde mutasyon tasiyan olgular sulfonilure tedavisinden fayda gorebilirler.
Mutations in the genes ABCC8
and KCNJ11 coding SUR1 and [K.
Although mutations are present in KCNJ11, ABCC8
and INS genes in approximately half of the cases with neonatal diabetes, the cause is still not known in about 30% (1-3).
Other mutations in the ABCC8
gene, which encodes the Sur1 sulfonylurea receptor in [beta]-cells, cause neonatal diabetes, and, as noted above, these neonatal diabetes patients are often sulfonylurea sensitive.
Activating mutations in the ABCC8
gene in neonatal diabetes mellitus.
2) and ABCC8
(SUR1) in relation to glucose intolerance: population-based studies and metaanalyses.
More than 100 mutations of ABCC8
and 20 mutations of KCNJ11 have been found.