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Cleavage in circulating monocytes /macrophages results in the generation of smaller fragments, called AA protein that can then deposit in the tissues.
AA amyloidosis was identified by using the peroxidase-antiperoxidase method using an antibody against AA protein (M 0759; Dako, Carpinteria, California).
The desired PCR product (~447 bp) was obtained and encoded a 148 AA protein that contained a signal peptide of 18 AA followed by a mature 130 AA protein (Figure 1).
They are also serum precursors of AA proteins, the chief constituents of reactive amyloid deposits [4].