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Recent studies at UCSD suggest that some of the autistic patients with elevated urate levels also have evidence of abnormally high rates of intracellular purine synthesis further indicating that they have a purine metabolism defect.
Forodesine is an orally-available transition-state analog inhibitor of purine nucleoside phosphorylase (PNP), a purine salvage pathway enzyme that is essential for the proliferation of T-cells and B-cells.
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